- Immunomodulatory interventions for focal epilepsy syndromes
Cochrane Systematic Reviews, 26-Jun-2013
Epilepsy is a common neurological disorder made particularly disabling in the 30% of patients who do not achieve freedom from seizures despite multiple trials of antiepileptic drugs (AEDs). Experimental and clinical evidence supports a role for inflammato - Immunomodulatory treatment other than corticosteroids, immunoglobulin and plasma exchange for chronic inflammatory demyelinating polyradiculoneuropathy
Cochrane Systematic Reviews, 8-May-2017
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a disease that causes progressive or relapsing and remitting weakness and numbness. It is probably caused by an autoimmune process. Immunosuppressive or immunomodulatory drugs would be ex - Immunonutrition as an adjuvant therapy for burns
Cochrane Systematic Reviews, 23-Dec-2014
With burn injuries involving a large total body surface area (TBSA), the body can enter a state of breakdown, resulting in a condition similar to that seen with severe lack of proper nutrition. In addition, destruction of the effective skin barrier leads - Immunonutrition for acute respiratory distress syndrome (ARDS) in adults
Cochrane Systematic Reviews, 24-Jan-2019
Acute respiratory distress syndrome (ARDS) is an overwhelming systemic inflammatory process associated with significant morbidity and mortality. Pharmacotherapies that moderate inflammation in ARDS are lacking. Several trials have evaluated the effects of - Immunonutrition for patients undergoing surgery for head and neck cancer
Cochrane Systematic Reviews, 30-Aug-2018
Patients with head and neck cancer are often malnourished. Surgery for such cancers is complex and may be undertaken after a course of radiotherapy. As a result, patients may have postoperative complications such as fistulae and wound infections, as well - Immunostimulants for preventing respiratory tract infection in children
Cochrane Systematic Reviews, 18-Oct-2006
Acute respiratory tract infections (ARTIs) are a major cause of childhood morbidity and mortality. Immunostimulants (IS) may reduce the incidence of ARTIs. - Immunosuppressant and immunomodulatory treatment for dermatomyositis and polymyositis
Cochrane Systematic Reviews, 15-Aug-2012
Idiopathic inflammatory myopathies are chronic diseases with significant mortality and morbidity. Whilst immunosuppressive and immunomodulatory therapies are frequently used, the optimal therapeutic regimen remains unclear. This is an update of a review f - Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy
Cochrane Systematic Reviews, 4-Mar-2015
Multifocal motor neuropathy (MMN) is characterised by progressive, predominantly distal, asymmetrical limb weakness and usually multiple partial motor nerve conduction blocks. Intravenous immunoglobulin (IVIg) is beneficial but the role of immunosuppressi - Immunosuppressants for the prophylaxis of corneal graft rejection after penetrating keratoplasty
Cochrane Systematic Reviews, 27-Aug-2015
Penetrating keratoplasty is a corneal transplantation procedure in which a full-thickness cornea from the host is replaced by a graft from a donor. The use of various immunosuppressants to prevent graft rejection, the most common cause of graft failure in - Immunosuppressive agents for myasthenia gravis
Cochrane Systematic Reviews, 2-Nov-2008
The benefits of different immunosuppressants for myasthenia gravis (MG) are unclear. - Immunosuppressive agents for treating IgA nephropathy
Cochrane Systematic Reviews, 12-Mar-2020
IgA nephropathy is the most common glomerulonephritis world-wide. IgA nephropathy causes end-stage kidney disease (ESKD) in 15% to 20% of affected patients within 10 years and in 30% to 40% of patients within 20 years from the onset of disease. This is an - Immunosuppressive and cytotoxic therapy for pulmonary sarcoidosis
Cochrane Systematic Reviews, 19-Jul-2006
Immunosuppressive and cytotoxic agents have been used as both an alternative to oral corticosteroids, and as a means of maintaining a low dose of steroids in the treatment of pulmonary sarcoidosis. - Immunosuppressive drug therapy for preventing rejection following lung transplantation in cystic fibrosis
Cochrane Systematic Reviews, 19-Jun-2018
For people with cystic fibrosis and advanced pulmonary damage, lung transplantation is an available and viable option. However, graft rejection is an important potential consequence after lung transplantation. Immunosuppressive therapy is needed to preven - Immunosuppressive T-cell antibody induction for heart transplant recipients
Cochrane Systematic Reviews, 1-Dec-2013
Heart transplantation has become a valuable and well-accepted treatment option for end-stage heart failure. Rejection of the transplanted heart by the recipient's body is a risk to the success of the procedure, and life-long immunosuppression is necessary - Immunosuppressive treatment for non-systemic vasculitic neuropathy
Cochrane Systematic Reviews, 3-Apr-2013
Non-systemic vasculitic neuropathy is a rare disabling disease that usually has a subacute onset of progressive or relapsing-remitting sensory or sensorimotor deficits. Asymmetry, pain and weakness are key features. The diagnosis can only be made by exclu - Immunosuppressive treatment for primary membranous nephropathy in adults with nephrotic syndrome
Cochrane Systematic Reviews, 15-Nov-2021
Primary membranous nephropathy (PMN) is a common cause of nephrotic syndrome in adults. Without treatment, approximately 30% of patients will experience spontaneous remission and one third will have persistent proteinuria. Approximately one-third of patie - Immunosuppressive treatment for proliferative lupus nephritis
Cochrane Systematic Reviews, 29-Jun-2018
Cyclophosphamide, in combination with corticosteroids, has been first-line treatment for inducing disease remission for proliferative lupus nephritis, reducing death at five years from over 50% in the 1950s and 1960s to less than 10% in recent years. Seve - Immunotherapy (excluding checkpoint inhibitors) for stage I to III non‐small cell lung cancer treated with surgery or radiotherapy with curative intent
Cochrane Systematic Reviews, 6-Dec-2021
Non-small cell lung cancer (NSCLC) is the most common lung cancer, accounting for approximately 80% to 85% of all cases. For people with localised NSCLC (stages I to III), it has been speculated that immunotherapy may be helpful for reducing postoperative - Immunotherapy (oral and sublingual) for food allergy to fruits
Cochrane Systematic Reviews, 9-Nov-2015
Food allergy is an abnormal immunological response following exposure (usually ingestion) to a food. Elimination of the allergen is the principle treatment for food allergy, including allergy to fruit. Accidental ingestion of allergenic foods can result i - Immunotherapy for advanced renal cell cancer
Cochrane Systematic Reviews, 29-Dec-2015
The course of advanced renal cell carcinoma is extremely variable, ranging from spontaneous remission to disease progression refractory to chemotherapy. Immunotherapy has held promise of improved outcomes based on uncontrolled studies and randomized contr
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