- Antihypertensive pharmacotherapy for prevention of sudden cardiac death in hypertensive individuals
Cochrane Systematic Reviews, 3-Mar-2016
High blood pressure is an important public health problem because of associated risks of stroke and cardiovascular events. Antihypertensive drugs are often used in the belief that lowering blood pressure will prevent cardiac events, including myocardial i - Antihypertensive therapy for preventing cardiovascular complications in people with diabetes mellitus
Cochrane Systematic Reviews, 9-Nov-2008
Hypertension and diabetes mellitus are closely associated diseases which are both strongly related to the risk of cardiovascular disease. - Antihypertensive withdrawal for the prevention of cognitive decline
Cochrane Systematic Reviews, 1-Nov-2016
Clinical trials and observational data have variously shown a protective, harmful or neutral effect of antihypertensives on cognitive function. In theory, withdrawal of antihypertensives could improve cerebral perfusion and reduce or delay cognitive decli - Anti-IL-12/23p40 antibodies for induction of remission in Crohn's disease
Cochrane Systematic Reviews, 24-Nov-2016
Ustekinumab (CNTO 1275) and briakinumab (ABT-874) are monoclonal antibodies that target the standard p40 subunit of the cytokines interleukin-12 and interleukin-23 (IL-12/23p40), which are involved in the pathogenesis of Crohn's disease. - Anti-IL5 therapies for asthma
Cochrane Systematic Reviews, 21-Sep-2017
This review is the first update of a previously published review in The Cochrane Library (Issue 7, 2015). Interleukin-5 (IL-5) is the main cytokine involved in the activation of eosinophils, which cause airway inflammation and are a classic feature of ast - Antimalarials for treating rheumatoid arthritis
Cochrane Systematic Reviews, 24-May-2010
Antimalarials have been used for the treatment of rheumatoid arthritis (RA) for several decades. Recently several trials have been published with larger sample sizes, and better design than previous studies. These newer trials have evaluated the efficacy - Antimetabolites in cataract surgery to prevent failure of a previous trabeculectomy
Cochrane Systematic Reviews, 20-Jul-2014
Patients having cataract surgery have often earlier undergone a trabeculectomy for glaucoma. However, cataract surgery may be associated with failure of the previous glaucoma surgery and antimetabolites may be used with cataract surgery to prevent such fa - Antimicrobial agents for preventing peritonitis in peritoneal dialysis patients
Cochrane Systematic Reviews, 8-Jun-2017
Peritoneal dialysis (PD) is an important therapy for patients with end-stage kidney disease and is used in more than 200,000 such patients globally. However, its value is often limited by the development of infections such as peritonitis and exit-site and - Antimicrobial agents for treating uncomplicated urinary tract infection in women
Cochrane Systematic Reviews, 8-Nov-2010
Acute uncomplicated lower urinary tract infection (UTI) is one of the most common problems for which young women seek medical attention. - Antimicrobial drugs for treating cholera
Cochrane Systematic Reviews, 12-Jun-2014
Cholera is an acute watery diarrhoea caused by infection with the bacterium Vibrio cholerae, which if severe can cause rapid dehydration and death. Effective management requires early diagnosis and rehydration using oral rehydration salts or intravenous f - Antimicrobial lock solutions for preventing catheter-related infections in haemodialysis
Cochrane Systematic Reviews, 30-Mar-2018
Patients undergoing haemodialysis (HD) through a central venous catheter (CVC) are exposed to several risks, being a catheter-related infection (CRI) and a CVC lumen thrombosis among the most serious. Standard of care regarding CVCs includes their sealing - Antimicrobial prophylaxis for colorectal surgery
Cochrane Systematic Reviews, 27-Aug-2015
Research shows that administration of prophylactic antibiotics before colorectal surgery prevents postoperative surgical wound infection. The best antibiotic choice, timing of administration and route of administration remain undetermined. - Antimicrobial therapy for chronic bacterial prostatitis
Cochrane Systematic Reviews, 2-Aug-2013
Chronic bacterial prostatitis (CBP) is frequently diagnosed in men of fertile age, and is characterized by a disabling array of symptoms, including pain in the pelvic area (for example, perineum, testicles), voiding symptoms (increased frequency and urgen - Antimicrobial-impregnated central venous catheters for prevention of catheter-related bloodstream infection in newborn infants
Cochrane Systematic Reviews, 24-Sep-2015
Central venous catheter-related bloodstream infection is an important cause of mortality and morbidity in newborn infants cared for in neonatal units. Potential strategies to prevent these infections include the use of central venous catheters impregnated - Antimotility agents for chronic diarrhoea in people with HIV/AIDS
Cochrane Systematic Reviews, 13-Aug-2008
AIDS-related diarrhoea is a common cause of morbidity and mortality in HIV positive individuals, especially in the sub-Saharan Africa where 70% of deaths from HIV occur. It often compromises quality of life both in those receiving antiretroviral therapy ( - Antioxidant supplements for liver diseases
Cochrane Systematic Reviews, 15-Feb-2011
Several liver diseases have been associated with oxidative stress. Accordingly, antioxidants have been suggested as potential therapeutics for various liver diseases. The evidence supporting these suggestions is equivocal. - Antioxidant supplements for non-alcoholic fatty liver disease and/or steatohepatitis
Cochrane Systematic Reviews, 22-Sep-2008
Non-alcoholic fatty liver disease (NAFLD) is characterised by fatty deposition in the hepatocytes of patients with minimal or no alcohol intake and without other known cause. NAFLD includes a wide spectrum of histologic abnormalities ranging from hepatic - Antioxidant supplements for preventing gastrointestinal cancers
Cochrane Systematic Reviews, 25-May-2008
Oxidative stress may cause gastrointestinal cancers. The evidence on whether antioxidant supplements are effective in preventing gastrointestinal cancers is contradictory. - Antioxidant treatment for amyotrophic lateral sclerosis or motor neuron disease
Cochrane Systematic Reviews, 10-May-2011
Free radical accumulation and oxidative stress have been proposed as contributing to the progression of amyotrophic lateral sclerosis (or motor neuron disease). A range of antioxidant medications have been studied. This is an updated review. - Antioxidant treatments for schizophrenia
Cochrane Systematic Reviews, 19-Jan-2016
There is accumulating evidence that progressive changes in brain structure and function take place as schizophrenia unfolds. Among many possible candidates, oxidative stress may be one of the mediators of neuroprogression, grey matter loss and subsequent
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