- High flow nasal cannula for respiratory support in preterm infants
Cochrane Systematic Reviews, 17-Feb-2016
High flow nasal cannulae (HFNC) are small, thin, tapered binasal tubes that deliver oxygen or blended oxygen/air at gas flows of more than 1 L/min. HFNC are increasingly being used as a form of non-invasive respiratory support for preterm infants. - High frequency jet ventilation versus high frequency oscillatory ventilation for pulmonary dysfunction in preterm infants
Cochrane Systematic Reviews, 11-Apr-2016
Respiratory distress syndrome (RDS) is considered one of the major contributors to severe pulmonary dysfunction and consequent death in preterm infants. Despite widespread improvements in care, including increased utilization of antenatal steroids, use of - High frequency oscillatory ventilation versus conventional ventilation for infants with severe pulmonary dysfunction born at or near term
Cochrane Systematic Reviews, 25-Feb-2013
Pulmonary disease is a major cause of mortality and morbidity in term and near term infants. Conventional ventilation (CV) has been used for many years but may lead to lung injury, require the subsequent use of more invasive treatment such as extracorpore - High initial concentration versus low initial concentration sevoflurane for inhalational induction of anaesthesia
Cochrane Systematic Reviews, 27-Jun-2016
Sevoflurane induction for general anaesthesia has been reported to be safe, reliable and well accepted by patients. Sevoflurane induction uses either low or high initial concentrations. The low initial concentration technique involves initially administer - High protein supplementation in pregnancy
Cochrane Systematic Reviews, 23-Oct-2008
Background pending. - High versus low dose of initial thyroid hormone replacement for congenital hypothyroidism
Cochrane Systematic Reviews, 19-Nov-2008
Congenital hypothyroidism (CHT) affects approximately one in 3000 to 4000 infants. CHT is one of the most common preventable causes of learning difficulties. Optimal management of CHT requires early diagnosis and prompt treatment to avoid abnormal neurode - High versus low medium chain triglyceride content of formula for promoting short-term growth of preterm infants
Cochrane Systematic Reviews, 19-Feb-2008
In-hospital growth of most very low birth weight infants remains below the 10th percentile of reference intrauterine growth curves (Ehrenkranz 1999). To improve growth, fat is added to preterm formula in the form of medium chain triglycerides (MCT) or lon - High versus low positive end-expiratory pressure (PEEP) levels for mechanically ventilated adult patients with acute lung injury and acute respiratory distress syndrome
Cochrane Systematic Reviews, 17-Dec-2018
Mortality in patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) remains high. These patients require mechanical ventilation, but this modality has been associated with ventilator-induced lung injury. High levels of positi - High versus standard volume enteral feeds to promote growth in preterm or low birth weight infants
Cochrane Systematic Reviews, 8-Sep-2017
Breast milk alone, given at standard recommended volumes (150 to 180 mL/kg/d), is not adequate to meet the protein, energy, and other nutrient requirements of growing preterm or low birth weight infants. One strategy that may be used to address these pote - High-carbohydrate, high-protein, low-fat versus low-carbohydrate, high-protein, high-fat enteral feeds for burns
Cochrane Systematic Reviews, 18-Jan-2012
Severe burn injuries increase patients' metabolic needs. Aggressive high-protein enteral feeding is used in the post-burn period to improve recovery and healing. - High-dose chemotherapy and autologous bone marrow or stem cell transplantation versus conventional chemotherapy for women with early poor prognosis breast cancer
Cochrane Systematic Reviews, 22-May-2016
Overall survival rates are disappointing for women with early poor prognosis breast cancer. Autologous transplantation of bone marrow or peripheral stem cells (in which the woman is both donor and recipient) has been considered a promising technique becau - High-dose chemotherapy and autologous haematopoietic stem cell rescue for children with high-risk neuroblastoma
Cochrane Systematic Reviews, 1-Oct-2015
Despite the development of new treatment options, the prognosis of high-risk neuroblastoma patients is still poor; more than half of patients experience disease recurrence. High-dose chemotherapy and haematopoietic stem cell rescue (i.e. myeloablative the - High-dose chemotherapy followed by autologous stem cell transplantation for patients with relapsed/refractory Hodgkin lymphoma
Cochrane Systematic Reviews, 19-Jun-2013
Hodgkin lymphoma (HL) is one of the most common malignancies in young adults and has become curable for the majority of patients, even in advanced stage. After first-line therapy, 15% to 20% do not respond to treatment and relapse. For those patients, hig - High-dose chemotherapy for children and young adults with stage IV rhabdomyosarcoma
Cochrane Systematic Reviews, 8-Nov-2010
Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood. Prognosis for patients with metastatic disease has not improved significantly in the past decades. High-dose chemotherapy (HDC) seems to be an attractive option to treat minimal residua - High-dose chemotherapy with autologous stem cell transplantation in the first line treatment of aggressive Non-Hodgkin Lymphoma (NHL) in adults
Cochrane Systematic Reviews, 2-Apr-2011
High-dose chemotherapy with autologous stem cell support (HDT) has been proven effective in relapsed aggressive non-Hodgkin lymphoma (NHL). However, conflicting results of HDT as part of first-line treatment have been reported in randomised controlled tri - High-dose opioids for chronic non-cancer pain: an overview of Cochrane Reviews
Cochrane Systematic Reviews, 4-Jan-2018
Chronic pain is typically described as pain on most days for at least three months. Chronic non-cancer pain (CNCP) is any chronic pain that is not due to a malignancy. Chronic non-cancer pain in adults is a common and complex clinical issue where opioids - High-dose therapy with autologous stem cell transplantation versus chemotherapy or immuno-chemotherapy for follicular lymphoma in adults
Cochrane Systematic Reviews, 15-Nov-2011
Follicular lymphoma (FL) is the most common indolent and second most common Non-Hodgkin`s lymphoma (NHL) in the Western world. Standard treatment usually includes rituximab and chemotherapy. High-dose therapy (HDT) followed by autologous stem cell transpl - High-dose versus low-dose oxytocin for augmentation of delayed labour
Cochrane Systematic Reviews, 5-Jul-2013
A major cause of failure to achieve spontaneous vaginal birth is delay in labour due to presumed inefficient uterine action. Oxytocin is given to increase contractions and high-dose regimens may potentially increase the number of spontaneous vaginal birth - High-dose versus low-dose oxytocin infusion regimens for induction of labour at term
Cochrane Systematic Reviews, 21-Mar-2016
When women require induction of labour, oxytocin is the most common agent used, delivered by an intravenous infusion titrated to uterine contraction strength and frequency. There is debate over the optimum dose regimen and how it impacts on maternal and f - Higher versus lower amino acid intake in parenteral nutrition for newborn infants
Cochrane Systematic Reviews, 1-Mar-2018
Sick newborn and preterm infants frequently are not able to be fed enterally, necessitating parenteral fluid and nutrition. Potential benefits of higher parenteral amino acid (AA) intake for improved nitrogen balance, growth, and infant health may be outw
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