- Helminth therapy (worms) for induction of remission in inflammatory bowel disease
Cochrane Systematic Reviews, 14-Jan-2014
Inflammatory bowel disease (IBD) is a chronic, globally-occurring gastrointestinal disorder and a major cause of illness and disability. It is conventionally classified into Crohn’s disease (CD) and ulcerative colitis (UC). Helminths are parasitic worms w - Hematopoietic stem cell transplantation for Gaucher disease
Cochrane Systematic Reviews, 18-Sep-2017
Gaucher disease is the most common lysosomal storage disorder caused by a deficiency of the enzyme glucocerebrosidase. Current treatment of the disease involves a choice from enzyme replacement therapy, substrate reduction therapy and hemotopoietic stem c - Hematopoietic stem cell transplantation for people with sickle cell disease
Cochrane Systematic Reviews, 31-Mar-2016
Sickle cell disease is a genetic disorder involving a defect in the red blood cells due to its sickled hemoglobin. The main therapeutic interventions include preventive and supportive measures. Hematopoietic stem cell transplantations are carried out with - Hematopoietic stem cell transplantation for people with ß-thalassaemia major
Cochrane Systematic Reviews, 22-Nov-2016
Thalassemia is an inherited autosomal recessive blood disorder, caused by mutations in globin genes or their regulatory regions. This results in a reduced rate of synthesis of one of the globin chains that make up haemoglobin. In ß-thalassaemia major ther - Hemodialysis for lithium poisoning
Cochrane Systematic Reviews, 15-Sep-2015
Lithium salts, particularly lithium carbonate, are frequently used to treat bipolar disorder and mania. Lithium poisoning, which can occur as a result of reduced renal elimination, prescribing error, drug-drug interactions, or deliberate overdosage, produ - Heparin and related substances for preventing diabetic kidney disease
Cochrane Systematic Reviews, 1-Aug-2010
Diabetic kidney disease (DKD, also called diabetic nephropathy, DN) is the major cause of end-stage kidney disease (ESKD) in many countries and is associated with increased morbidity and mortality as compared to other causes of kidney disease. One of the - Heparin for assisted reproduction
Cochrane Systematic Reviews, 3-Sep-2014
Heparin as an adjunct in assisted reproduction (peri-implantation heparin) is given at or after egg collection or at embryo transfer. Heparin has been advocated to improve embryo implantation and clinical outcomes. It is proposed that heparin may enhance - Heparin for pregnant women with acquired or inherited thrombophilias
Cochrane Systematic Reviews, 8-Aug-2012
Thrombophilias, which are associated with a predisposition to thrombotic events, have been implicated in adverse obstetrical outcomes such as intrauterine growth restriction, stillbirth, severe early onset pre-eclampsia, and placental abruption. Heparin a - Heparin for prolonging peripheral intravenous catheter use in neonates
Cochrane Systematic Reviews, 14-Jun-2011
Mechanical or infectious complications often necessitate their removal and/or replacement of peripheral intravenous catheters. Heparin has been shown to be effective in prolonging the patency of peripheral arterial catheters and central venous catheters, - Heparin for the prevention of intraventricular haemorrhage in preterm infants
Cochrane Systematic Reviews, 5-May-2016
Preterm birth remains the major risk factor for the development of intraventricular haemorrhage, an injury that occurs in 25% of very low birth weight infants. Intraventricular haemorrhage is thought to be venous in origin and intrinsic thromboses in the - Heparin for the prevention of venous thromboembolism in acutely ill medical patients (excluding stroke and myocardial infarction)
Cochrane Systematic Reviews, 15-Feb-2018
Venous thromboembolic disease has been extensively studied in surgical patients. The benefit of thromboprophylaxis is now generally accepted, but it is medical patients who make up the greater proportion of the hospital population. Medical patients differ - Heparin for the treatment of thrombosis in neonates
Cochrane Systematic Reviews, 7-Nov-2016
Among pediatric patients, newborns are at highest risk of developing thromboembolism. Neonatal thromboembolic (TE) events may consist of both venous and arterial thromboses and often iatrogenic complications (eg, central catheterization). Treatment guidel - Heparin versus 0.9% sodium chloride intermittent flushing for the prevention of occlusion in long term central venous catheters in infants and children
Cochrane Systematic Reviews, 20-Nov-2015
Guidelines and clinical practice for the prevention of complications associated with central venous catheters (CVC) around the world vary greatly. Most institutions recommend the use of heparin to prevent occlusion, however there is debate regarding the n - Heparin versus normal saline for patency of arterial lines
Cochrane Systematic Reviews, 14-Dec-2018
For most patients who require intensive care, the success of clinical decision making and interventions is dependent on the accuracy of different physiological variables measured or obtained from samples using an arterial catheter. Maintaining the patency - Heparin versus placebo for non-ST elevation acute coronary syndromes
Cochrane Systematic Reviews, 24-Jun-2014
Non-ST elevation acute coronary syndromes (NSTEACS) represent a spectrum of disease including unstable angina and non-ST segment myocardial infarction (NSTEMI). Despite treatment with aspirin, beta-blockers and nitroglycerin, unstable angina/NSTEMI is sti - Heparin, low molecular weight heparin and physical methods for preventing deep vein thrombosis and pulmonary embolism following surgery for hip fractures
Cochrane Systematic Reviews, 10-Aug-2008
Hip fracture patients have a high risk of thrombo-embolic complications following surgical management. - Heparin-bonded catheters for prolonging the patency of central venous catheters in children
Cochrane Systematic Reviews, 25-Feb-2014
Central venous catheters (CVCs) are a mainstay in the management of critically ill children. However, these catheters are associated with mechanical and infectious complications which reduce their life span. Heparin bonding of catheters has shown promise - Heparins and mechanical methods for thromboprophylaxis in colorectal surgery
Cochrane Systematic Reviews, 23-Jul-2008
Colorectal surgery implies higher risk of postoperative thromboembolic complications as deep venous thrombosis (DVT) and pulmonary embolism (PE) than general surgery. The best prophylaxis in general surgery is heparin and graded compression stockings. No - Hepatic artery adjuvant chemotherapy for patients having resection or ablation of colorectal cancer metastatic to the liver
Cochrane Systematic Reviews, 30-Jul-2009
Colorectal cancer metastatic to the liver, when technically feasible, is resected with a moderate chance of cure. The most common site of failure after resection is within the remaining liver. With this pattern of clinical failure in mind and in order to - Hepatitis A immunisation in persons not previously exposed to hepatitis A
Cochrane Systematic Reviews, 17-Dec-2019
In many parts of the world, hepatitis A infection represents a significant cause of morbidity and socio-economic loss. Whilst hepatitis A vaccines have the potential to prevent disease, the degree of protection afforded against clinical outcomes and with
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