- High‐dose chemotherapy followed by autologous haematopoietic cell transplantation for children, adolescents, and young adults with primary metastatic Ewing sarcoma
Cochrane Systematic Reviews, 2-Sep-2021
Ewing sarcomas are solid tumours of the bone and soft tissue, that usually affect children, adolescents, and young adults. The incidence is about three cases per million a year, with a peak incidence at 12 years of age. Metastatic disease is detected in a - High-dose chemotherapy followed by autologous stem cell transplantation for patients with relapsed/refractory Hodgkin lymphoma
Cochrane Systematic Reviews, 19-Jun-2013
Hodgkin lymphoma (HL) is one of the most common malignancies in young adults and has become curable for the majority of patients, even in advanced stage. After first-line therapy, 15% to 20% do not respond to treatment and relapse. For those patients, hig - High-dose chemotherapy for children and young adults with stage IV rhabdomyosarcoma
Cochrane Systematic Reviews, 8-Nov-2010
Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood. Prognosis for patients with metastatic disease has not improved significantly in the past decades. High-dose chemotherapy (HDC) seems to be an attractive option to treat minimal residua - High‐dose chemotherapy with autologous stem cell transplantation in the first line treatment of aggressive Non‐Hodgkin Lymphoma (NHL) in adults
Cochrane Systematic Reviews, 23-Jan-2008
High-dose chemotherapy with autologous stem cell support (HDT) has been proven effective in relapsed aggressive non-Hodgkin lymphoma (NHL). However, conflicting results of HDT as part of first-line treatment have been reported in randomised controlled tri - High‐dose opioids for chronic non‐cancer pain: an overview of Cochrane Reviews
Cochrane Systematic Reviews, 30-Oct-2017
Chronic pain is typically described as pain on most days for at least three months. Chronic non-cancer pain (CNCP) is any chronic pain that is not due to a malignancy. Chronic non-cancer pain in adults is a common and complex clinical issue where opioids - High-dose therapy with autologous stem cell transplantation versus chemotherapy or immuno-chemotherapy for follicular lymphoma in adults
Cochrane Systematic Reviews, 15-Nov-2011
Follicular lymphoma (FL) is the most common indolent and second most common Non-Hodgkin`s lymphoma (NHL) in the Western world. Standard treatment usually includes rituximab and chemotherapy. High-dose therapy (HDT) followed by autologous stem cell transpl - High‐dose versus low‐dose oxytocin for augmentation of delayed labour
Cochrane Systematic Reviews, 13-Jul-2013
A major cause of failure to achieve spontaneous vaginal birth is delay in labour due to presumed inefficient uterine action. Oxytocin is given to increase contractions and high-dose regimens may potentially increase the number of spontaneous vaginal birth - High‐dose versus low‐dose oxytocin infusion regimens for induction of labour at term
Cochrane Systematic Reviews, 9-Oct-2014
When women require induction of labour, oxytocin is the most common agent used, delivered by an intravenous infusion titrated to uterine contraction strength and frequency. There is debate over the optimum dose regimen and how it impacts on maternal and f - Higher versus lower amino acid intake in parenteral nutrition for newborn infants
Cochrane Systematic Reviews, 5-Mar-2018
Sick newborn and preterm infants frequently are not able to be fed enterally, necessitating parenteral fluid and nutrition. Potential benefits of higher parenteral amino acid (AA) intake for improved nitrogen balance, growth, and infant health may be outw - Higher versus lower fraction of inspired oxygen or targets of arterial oxygenation for adults admitted to the intensive care unit
Cochrane Systematic Reviews, 27-Nov-2019
The mainstay treatment for hypoxaemia is oxygen therapy, which is given to the vast majority of adults admitted to the intensive care unit (ICU). The practice of oxygen administration has been liberal, which may result in hyperoxaemia. Some studies have i - Higher versus lower protein intake in formula‐fed low birth weight infants
Cochrane Systematic Reviews, 23-Jun-2020
The ideal quantity of dietary protein for formula-fed low birth weight infants is still a matter of debate. Protein intake must be sufficient to achieve normal growth without leading to negative effects such as acidosis, uremia, and elevated levels of cir - High-flow nasal cannula therapy for infants with bronchiolitis
Cochrane Systematic Reviews, 14-Jan-2014
Bronchiolitis is a common lower respiratory tract illness, usually of viral aetiology, affecting infants younger than 24 months of age and is a frequent cause of hospitalisation. It causes airway inflammation, mucus production and mucous plugging, resulti - High‐flow nasal cannula therapy for respiratory support in children
Cochrane Systematic Reviews, 7-Mar-2014
Respiratory support is a central component of the management of critically ill children. It can be delivered invasively via an endotracheal tube or non-invasively via face mask, nasal mask, nasal cannula or oxygen hood/tent. Invasive ventilation can be da - High‐flow nasal cannulae for respiratory support in adult intensive care patients
Cochrane Systematic Reviews, 4-Mar-2021
High-flow nasal cannulae (HFNC) deliver high flows of blended humidified air and oxygen via wide-bore nasal cannulae and may be useful in providing respiratory support for adults experiencing acute respiratory failure, or at risk of acute respiratory fail - High‐flux versus low‐flux membranes for end‐stage kidney disease
Cochrane Systematic Reviews, 12-Sep-2012
Clinical practice guidelines regarding the use of high-flux haemodialysis membranes vary widely. - High‐frequency oscillatory ventilation versus conventional ventilation for acute respiratory distress syndrome
Cochrane Systematic Reviews, 4-Apr-2016
High-frequency oscillation (HFO) is an alternative to conventional mechanical ventilation that is sometimes used to treat people with acute respiratory distress syndrome, but effects on oxygenation, mortality and adverse clinical outcomes are uncertain. T - High‐frequency ultrasound for diagnosing skin cancer in adults
Cochrane Systematic Reviews, 4-Dec-2018
Early, accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high-risk skin cancers with the potential to metastasise and ultimately l - High‐intensity versus low‐intensity physical activity or exercise in people with hip or knee osteoarthritis
Cochrane Systematic Reviews, 29-Oct-2015
Exercise or physical activity is recommended for improving pain and functional status in people with knee or hip osteoarthritis. These are complex interventions whose effectiveness depends on one or more components that are often poorly identified. It has - High‐volume haemofiltration for sepsis in adults
Cochrane Systematic Reviews, 31-Jan-2017
Severe sepsis and septic shock are leading causes of death in the intensive care unit (ICU), despite advances in the treatment of patients with severe sepsis and septic shock, including early recognition, appropriate treatment with antibiotics and support - Hip protectors for preventing hip fractures in older people
Cochrane Systematic Reviews, 31-Mar-2014
Older people living in nursing care facilities or older adults living at home are at high risk of falling and a hip fracture may occur after a fall. Hip protectors have been advocated as a means to reduce the risk of hip fracture. Hip protectors are plast
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