- High-carbohydrate, high-protein, low-fat versus low-carbohydrate, high-protein, high-fat enteral feeds for burns
Cochrane Systematic Reviews, 18-Jan-2012
Severe burn injuries increase patients' metabolic needs. Aggressive high-protein enteral feeding is used in the post-burn period to improve recovery and healing. - High‐dose chemotherapy and autologous bone marrow or stem cell transplantation versus conventional chemotherapy for women with early poor prognosis breast cancer
Cochrane Systematic Reviews, 22-May-2016
Overall survival rates are disappointing for women with early poor prognosis breast cancer. Autologous transplantation of bone marrow or peripheral stem cells (in which the woman is both donor and recipient) has been considered a promising technique becau - High‐dose chemotherapy and autologous bone marrow or stem cell transplantation versus conventional chemotherapy for women with metastatic breast cancer
Cochrane Systematic Reviews,
Although metastatic breast cancer is often responsive to conventional chemotherapy, it remains ultimately incurable. Autologous transplantation of bone marrow or peripheral stem cells (in which the patient is both donor and recipient) has been considered - High‐dose chemotherapy and autologous haematopoietic stem cell rescue for children with high‐risk neuroblastoma
Cochrane Systematic Reviews, 1-Oct-2015
Despite the development of new treatment options, the prognosis of high-risk neuroblastoma patients is still poor; more than half of patients experience disease recurrence. High-dose chemotherapy and haematopoietic stem cell rescue (i.e. myeloablative the - High‐dose chemotherapy followed by autologous haematopoietic cell transplantation for children, adolescents, and young adults with first recurrence of Ewing sarcoma
Cochrane Systematic Reviews,
Ewing sarcoma is a solid tumour, which is the second most common primary bone malignancy in children, often occurring in the long bones and pelvis. An incidence rate of 4.5 per million a year is reported, with a peak incidence of 11 per million at the age - High‐dose chemotherapy followed by autologous haematopoietic cell transplantation for children, adolescents, and young adults with primary metastatic Ewing sarcoma
Cochrane Systematic Reviews,
Ewing sarcomas are solid tumours of the bone and soft tissue, that usually affect children, adolescents, and young adults. The incidence is about three cases per million a year, with a peak incidence at 12 years of age. Metastatic disease is detected in a - High-dose chemotherapy followed by autologous stem cell transplantation for patients with relapsed/refractory Hodgkin lymphoma
Cochrane Systematic Reviews, 19-Jun-2013
Hodgkin lymphoma (HL) is one of the most common malignancies in young adults and has become curable for the majority of patients, even in advanced stage. After first-line therapy, 15% to 20% do not respond to treatment and relapse. For those patients, hig - High-dose chemotherapy for children and young adults with stage IV rhabdomyosarcoma
Cochrane Systematic Reviews, 8-Nov-2010
Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood. Prognosis for patients with metastatic disease has not improved significantly in the past decades. High-dose chemotherapy (HDC) seems to be an attractive option to treat minimal residua - High-dose chemotherapy with autologous stem cell transplantation in the first line treatment of aggressive Non-Hodgkin Lymphoma (NHL) in adults
Cochrane Systematic Reviews, 2-Apr-2011
High-dose chemotherapy with autologous stem cell support (HDT) has been proven effective in relapsed aggressive non-Hodgkin lymphoma (NHL). However, conflicting results of HDT as part of first-line treatment have been reported in randomised controlled tri - High‐dose opioids for chronic non‐cancer pain: an overview of Cochrane Reviews
Cochrane Systematic Reviews, 4-Jan-2018
Chronic pain is typically described as pain on most days for at least three months. Chronic non-cancer pain (CNCP) is any chronic pain that is not due to a malignancy. Chronic non-cancer pain in adults is a common and complex clinical issue where opioids - High-dose therapy with autologous stem cell transplantation versus chemotherapy or immuno-chemotherapy for follicular lymphoma in adults
Cochrane Systematic Reviews, 15-Nov-2011
Follicular lymphoma (FL) is the most common indolent and second most common Non-Hodgkin`s lymphoma (NHL) in the Western world. Standard treatment usually includes rituximab and chemotherapy. High-dose therapy (HDT) followed by autologous stem cell transpl - High‐dose versus low‐dose oxytocin for augmentation of delayed labour
Cochrane Systematic Reviews, 5-Jul-2013
A major cause of failure to achieve spontaneous vaginal birth is delay in labour due to presumed inefficient uterine action. Oxytocin is given to increase contractions and high-dose regimens may potentially increase the number of spontaneous vaginal birth - High-dose versus low-dose oxytocin infusion regimens for induction of labour at term
Cochrane Systematic Reviews, 21-Mar-2016
When women require induction of labour, oxytocin is the most common agent used, delivered by an intravenous infusion titrated to uterine contraction strength and frequency. There is debate over the optimum dose regimen and how it impacts on maternal and f - Higher versus lower amino acid intake in parenteral nutrition for newborn infants
Cochrane Systematic Reviews, 1-Mar-2018
Sick newborn and preterm infants frequently are not able to be fed enterally, necessitating parenteral fluid and nutrition. Potential benefits of higher parenteral amino acid (AA) intake for improved nitrogen balance, growth, and infant health may be outw - Higher versus lower fraction of inspired oxygen or targets of arterial oxygenation for adults admitted to the intensive care unit
Cochrane Systematic Reviews, 27-Nov-2019
The mainstay treatment for hypoxaemia is oxygen therapy, which is given to the vast majority of adults admitted to the intensive care unit (ICU). The practice of oxygen administration has been liberal, which may result in hyperoxaemia. Some studies have i - Higher versus lower protein intake in formula‐fed low birth weight infants
Cochrane Systematic Reviews,
The ideal quantity of dietary protein for formula-fed low birth weight infants is still a matter of debate. Protein intake must be sufficient to achieve normal growth without leading to negative effects such as acidosis, uremia, and elevated levels of cir - High-flow nasal cannula therapy for infants with bronchiolitis
Cochrane Systematic Reviews, 14-Jan-2014
Bronchiolitis is a common lower respiratory tract illness, usually of viral aetiology, affecting infants younger than 24 months of age and is a frequent cause of hospitalisation. It causes airway inflammation, mucus production and mucous plugging, resulti - High‐flow nasal cannula therapy for respiratory support in children
Cochrane Systematic Reviews, 20-Dec-2018
Respiratory support is a central component of the management of critically ill children. It can be delivered invasively via an endotracheal tube or non-invasively via face mask, nasal mask, nasal cannula or oxygen hood/tent. Invasive ventilation can be da - High‐flow nasal cannulae for respiratory support in adult intensive care patients
Cochrane Systematic Reviews,
High-flow nasal cannulae (HFNC) deliver high flows of blended humidified air and oxygen via wide-bore nasal cannulae and may be useful in providing respiratory support for adults experiencing acute respiratory failure, or at risk of acute respiratory fail - High‐flux versus low‐flux membranes for end‐stage kidney disease
Cochrane Systematic Reviews, 1-Feb-2016
Clinical practice guidelines regarding the use of high-flux haemodialysis membranes vary widely.
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