- First‐line combination therapy versus first‐line monotherapy for primary hypertension
Cochrane Systematic Reviews, 6-Feb-2020
This is the second update of a review originally published in 2017. Starting with one drug and with a combination of two drugs are strategies suggested in clinical guidelines as initial treatment for hypertension. The recommendations are not based on evid - First‐line drugs for hypertension
Cochrane Systematic Reviews, 18-Apr-2018
This is the first update of a review published in 2009. Sustained moderate to severe elevations in resting blood pressure leads to a critically important clinical question: What class of drug to use first-line? This review attempted to answer that questio - First‐line drugs inhibiting the renin angiotensin system versus other first‐line antihypertensive drug classes for hypertension
Cochrane Systematic Reviews, 14-Nov-2018
This is the first update of a Cochrane Review first published in 2015. Renin angiotensin system (RAS) inhibitors include angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs) and renin inhibitors. They are widely prescribed - First-line tandem high-dose chemotherapy and autologous stem cell transplantation versus single high-dose chemotherapy and autologous stem cell transplantation in multiple myeloma, a systematic review of controlled studies
Cochrane Systematic Reviews, 14-Aug-2012
Several clinical studies have compared single with tandem (also called double) autologous stem cell transplantation (ASCT) as first-line treatment in patients with symptomatic multiple myeloma (MM), one of the leading indications for ASCT worldwide. - First‐line treatment of advanced epidermal growth factor receptor (EGFR) mutation positive non‐squamous non‐small cell lung cancer
Cochrane Systematic Reviews, 18-Mar-2021
Epidermal growth factor receptor (EGFR) mutation positive (M+) non-small cell lung cancer (NSCLC) is an important subtype of lung cancer comprising 10% to 15% of non-squamous tumours. This subtype is more common in women than men, is less associated with - Fish oil for induction of remission in ulcerative colitis
Cochrane Systematic Reviews, 26-May-2008
Fish oil supplements, which are rich in n-3 fatty acids, may reduce inflammation, decrease the need for anti-inflammatory drugs, and promote normal weight gain in people with ulcerative colitis. - Fish oil for kidney transplant recipients
Cochrane Systematic Reviews, 18-Aug-2016
Calcineurin inhibitors used in kidney transplantation for immunosuppression have adverse effects that may contribute to nephrotoxicity and increased cardiovascular risk profile. Fish oils are rich in very long chain omega-3 fatty acids, which may reduce n - Fitness training for cardiorespiratory conditioning after traumatic brain injury
Cochrane Systematic Reviews, 29-Dec-2017
Reduced cardiorespiratory fitness (cardiorespiratory deconditioning) is a common consequence of traumatic brain injury (TBI). Fitness training may be implemented to address this impairment. - Fixed dose subcutaneous low molecular weight heparins versus adjusted dose unfractionated heparin for the initial treatment of venous thromboembolism
Cochrane Systematic Reviews, 9-Feb-2017
Low molecular weight heparins (LMWHs) have been shown to be effective and safe in preventing venous thromboembolism (VTE). They may also be effective for the initial treatment of VTE. This is the third update of the Cochrane Review first published in 1999 - Fixed‐dose combination therapy for the prevention of atherosclerotic cardiovascular diseases
Cochrane Systematic Reviews, 6-Mar-2017
Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death and disability worldwide, yet ASCVD risk factor control and secondary prevention rates remain low. A fixed-dose combination of blood pressure- and cholesterol-lowering and antipl - Fixed‐dose combinations of drugs versus single‐drug formulations for treating pulmonary tuberculosis
Cochrane Systematic Reviews, 17-May-2016
People who are newly diagnosed with pulmonary tuberculosis (TB) typically receive a standard first-line treatment regimen that consists of two months of isoniazid, rifampicin, pyrazinamide, and ethambutol followed by four months of isoniazid and rifampici - Flavonoids for treating venous leg ulcers
Cochrane Systematic Reviews, 24-Apr-2013
Venous leg ulcers are a major health burden: annually, in the UK alone, they contribute an estimated cost to the NHS of GBP 400 million. Flavonoids are a diverse group of naturally-occurring venotonic compounds that address certain microcirculatory parame - Flexibility exercise training for adults with fibromyalgia
Cochrane Systematic Reviews, 2-Sep-2019
Exercise training is commonly recommended for adults with fibromyalgia. We defined flexibility exercise training programs as those involving movements of a joint or a series of joints, through complete range of motion, thus targeting major muscle-tendon u - Flexible sigmoidoscopy versus faecal occult blood testing for colorectal cancer screening in asymptomatic individuals
Cochrane Systematic Reviews, 1-Oct-2013
Colorectal cancer is the third most frequent cancer in the world. As the sojourn time for this cancer is several years and a good prognosis is associated with early stage diagnosis, screening has been implemented in a number of countries. Both screening w - Flexible working conditions and their effects on employee health and wellbeing
Cochrane Systematic Reviews, 17-Feb-2010
Flexible working conditions are increasingly popular in developed countries but the effects on employee health and wellbeing are largely unknown. - Flossing for the management of periodontal diseases and dental caries in adults
Cochrane Systematic Reviews, 23-Apr-2019
Good oral hygiene is thought to be important for oral health. This review is to determine the effectiveness of flossing in addition to toothbrushing for preventing gum disease and dental caries in adults. - Flow-cycled versus time-cycled synchronized ventilation for neonates
Cochrane Systematic Reviews, 15-Jun-2010
Synchronized ventilation of neonates is standard care in industrialized countries. Both flow-cycled and time-cycled modes of synchronized ventilation are in widespread use for assisted ventilation of neonates. - Flow-regulated versus differential pressure-regulated shunt valves for adult patients with normal pressure hydrocephalus
Cochrane Systematic Reviews, 23-Apr-2013
Since 1965 many ventriculo-peritoneal shunt systems have been inserted worldwide to treat hydrocephalus. The most frequent indication in adults is normal pressure hydrocephalus (NPH), a condition that can be difficult to diagnose precisely. Surgical inter - Fludrocortisone for orthostatic hypotension
Cochrane Systematic Reviews, 17-May-2021
Orthostatic hypotension is an excessive fall in blood pressure (BP) while standing and is the result of a decrease in cardiac output or defective or inadequate vasoconstrictor mechanisms. Fludrocortisone is a mineralocorticoid that increases blood volume - Fluid and pharmacological agents for adhesion prevention after gynaecological surgery
Cochrane Systematic Reviews, 19-Jul-2020
Adhesions are fibrin bands that are a common consequence of gynaecological surgery. They are caused by conditions that include pelvic inflammatory disease and endometriosis. Adhesions are associated with comorbidities, including pelvic pain, subfertility,
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