- Finasteride for benign prostatic hyperplasia
Cochrane Systematic Reviews, 17-Dec-2015
Benign prostatic hyperplasia (BPH), a non-malignant enlargement of the prostate in aging men, can cause bothersome urinary symptoms (intermittency, weak stream, straining, urgency, frequency, incomplete emptying). Finasteride, a five-alpha reductase inhib - Fingolimod for relapsing-remitting multiple sclerosis
Cochrane Systematic Reviews, 15-Apr-2016
Fingolimod was approved in 2010 for the treatment of patients with the relapsing-remitting (RR) form of multiple sclerosis (MS). It was designed to reduce the frequency of exacerbations and to delay disability worsening. Issues on its safety and efficacy, - First aid glucose administration routes for symptomatic hypoglycaemia
Cochrane Systematic Reviews, 10-Apr-2019
Hypoglycaemia is a common occurrence in people with diabetes but can also result from an imbalance in glucose homeostasis in the absence of diabetes. The best enteral route for glucose administration for suspected hypoglycaemia in a first aid situation is - First aid interventions by laypeople for acute oral poisoning
Cochrane Systematic Reviews, 8-Jul-2019
Oral poisoning is a major cause of mortality and disability worldwide, with estimates of over 100,000 deaths due to unintentional poisoning each year and an overrepresentation of children below five years of age. Any effective intervention that laypeople - First and second trimester serum tests with and without first trimester ultrasound tests for Down's syndrome screening
Cochrane Systematic Reviews, 15-Mar-2017
Down's syndrome occurs when a person has three copies of chromosome 21 (or the specific area of chromosome 21 implicated in causing Down's syndrome) rather than two. It is the commonest congenital cause of mental disability. Non-invasive screening based o - First rank symptoms for schizophrenia
Cochrane Systematic Reviews, 7-Jan-2015
Early and accurate diagnosis and treatment of schizophrenia may have long-term advantages for the patient; the longer psychosis goes untreated the more severe the repercussions for relapse and recovery. If the correct diagnosis is not schizophrenia, but a - First trimester serum tests for Down's syndrome screening
Cochrane Systematic Reviews, 25-Nov-2015
Down's syndrome occurs when a person has three, rather than two copies of chromosome 21; or the specific area of chromosome 21 implicated in causing Down's syndrome. It is the commonest congenital cause of mental disability and also leads to numerous meta - First trimester ultrasound tests alone or in combination with first trimester serum tests for Down's syndrome screening
Cochrane Systematic Reviews, 15-Mar-2017
Down's syndrome occurs when a person has three, rather than two copies of chromosome 21; or the specific area of chromosome 21 implicated in causing Down's syndrome. It is the commonest congenital cause of mental disability and also leads to numerous meta - First-line allogeneic hematopoietic stem cell transplantation of HLA-matched sibling donors compared with first-line ciclosporin and/or antithymocyte or antilymphocyte globulin for acquired severe aplastic anemia
Cochrane Systematic Reviews, 19-Jul-2013
Acquired severe aplastic anemia is a rare and potentially fatal disease, which is characterized by hypocellular bone marrow and pancytopenia. The major signs and symptoms are severe infections, bleeding, and exhaustion. First-line allogeneic hematopoietic - First-line beta-blockers versus other antihypertensive medications for chronic type B aortic dissection
Cochrane Systematic Reviews, 26-Feb-2014
Thoracic aortic dissection (TAD) is a severe and often lethal complication in people with hypertension. Current practice in the treatment of chronic type B aortic dissections is the use of beta-blockers as first-line therapy to decrease aortic wall stress - First‐line chemotherapy in low‐risk gestational trophoblastic neoplasia
Cochrane Systematic Reviews, 30-Sep-2019
This is the second update of a Cochrane review that was first published in 2009, Issue 1. Gestational trophoblastic neoplasia (GTN) is a rare but curable disease arising in the fetal chorion during pregnancy. Most women with low-risk GTN will be cured by - First‐line combination therapy versus first‐line monotherapy for primary hypertension
Cochrane Systematic Reviews, 5-Feb-2020
This is the first update of a review originally published in 2017. Starting with one drug and starting with a combination of two drugs are strategies suggested in clinical guidelines as initial treatment of hypertension. The recommendations are not based - First‐line drugs for hypertension
Cochrane Systematic Reviews, 17-Apr-2018
This is the first update of a review published in 2009. Sustained moderate to severe elevations in resting blood pressure leads to a critically important clinical question: What class of drug to use first-line? This review attempted to answer that questio - First-line drugs inhibiting the renin angiotensin system versus other first-line antihypertensive drug classes for hypertension
Cochrane Systematic Reviews, 14-Nov-2018
This is the first update of a Cochrane Review first published in 2015. Renin angiotensin system (RAS) inhibitors include angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs) and renin inhibitors. They are widely prescribed - First-line tandem high-dose chemotherapy and autologous stem cell transplantation versus single high-dose chemotherapy and autologous stem cell transplantation in multiple myeloma, a systematic review of controlled studies
Cochrane Systematic Reviews, 14-Aug-2012
Several clinical studies have compared single with tandem (also called double) autologous stem cell transplantation (ASCT) as first-line treatment in patients with symptomatic multiple myeloma (MM), one of the leading indications for ASCT worldwide. - First‐line treatment of advanced epidermal growth factor receptor (EGFR) mutation positive non‐squamous non‐small cell lung cancer
Cochrane Systematic Reviews,
Epidermal growth factor receptor (EGFR) mutation positive (M+) non-small cell lung cancer (NSCLC) is an important subtype of lung cancer comprising 10% to 15% of non-squamous tumours. This subtype is more common in women than men, is less associated with - Fish oil for induction of remission in ulcerative colitis
Cochrane Systematic Reviews, 26-May-2008
Fish oil supplements, which are rich in n-3 fatty acids, may reduce inflammation, decrease the need for anti-inflammatory drugs, and promote normal weight gain in people with ulcerative colitis. - Fish oil for kidney transplant recipients
Cochrane Systematic Reviews, 15-Aug-2016
Calcineurin inhibitors used in kidney transplantation for immunosuppression have adverse effects that may contribute to nephrotoxicity and increased cardiovascular risk profile. Fish oils are rich in very long chain omega-3 fatty acids, which may reduce n - Fitness training for cardiorespiratory conditioning after traumatic brain injury
Cochrane Systematic Reviews, 21-Dec-2017
Reduced cardiorespiratory fitness (cardiorespiratory deconditioning) is a common consequence of traumatic brain injury (TBI). Fitness training may be implemented to address this impairment. - Fixed dose subcutaneous low molecular weight heparins versus adjusted dose unfractionated heparin for the initial treatment of venous thromboembolism
Cochrane Systematic Reviews, 9-Feb-2017
Low molecular weight heparins (LMWHs) have been shown to be effective and safe in preventing venous thromboembolism (VTE). They may also be effective for the initial treatment of VTE. This is the third update of the Cochrane Review first published in 1999
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