- Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Hypofibrinogenaemia is associated with increased morbidity and mortality, but the optimal treatment level, the use of preemptive treatment and the preferred source of fibrinogen remain disputed. Fibrinogen concentrate is increasingly used and recommended - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Invasive pneumococcal disease is associated with significant mortality and many countries have introduced routine pneumococcal vaccination into their childhood immunisation programmes. Whilst pneumococcal disease in cystic fibrosis is uncommon, pneumococc - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Multiple pregnancies are associated with higher rates of perinatal mortality and morbidity than singleton pregnancies, mainly due to an increased risk of preterm birth. Because fetal outcome is best at a particular range of maternal weight gain, it has be - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Venom immunotherapy (VIT) is commonly used for preventing further allergic reactions to insect stings in people who have had a sting reaction. The efficacy and safety of this treatment has not previously been assessed by a high-quality systematic review. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Homocystinuria is a rare inherited disorder due to a deficiency in cystathionine beta synthase. Individuals with this condition appear normal at birth but develop serious complications in childhood. Diagnosis and treatment started sufficiently early in li - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Patients with chronic kidney disease (CKD) are at increased risk of coronary artery disease (CAD) and adverse cardiac events. Screening for CAD is therefore an important part of preoperative evaluation for kidney transplant candidates. There is significan - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Behavioural therapies represent one of several categories of psychological therapies that are currently used in the treatment of depression. However, the effectiveness and acceptability of behavioural therapies for depression compared with other psycholog - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Thalassemia is an inherited autosomal recessive blood disorder, caused by mutations in globin genes or their regulatory regions. This results in a reduced rate of synthesis of one of the globin chains that make up haemoglobin. In ß-thalassaemia major ther - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Vitamin D is a micronutrient important for bone growth and immune function. Deficiency can lead to rickets and has been linked to various infections, including respiratory infections. The evidence on the effects of supplementation on infections in childre - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Shoulder pain is a very common symptom. Disorders of the rotator cuff tendons due to wear or tear are among the most common causes of shoulder pain and disability. Magnetic resonance imaging (MRI), magnetic resonance arthrography (MRA) and ultrasound (US) - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
There are many pathological conditions leading to an elevated unconjugated bilirubin level (hyperbilirubinaemia) in neonates. Currently the standard therapies for unconjugated hyperbilirubinaemia include phototherapy and exchange transfusion. In addition - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
General health checks are common elements of health care in some countries. They aim to detect disease and risk factors for disease with the purpose of reducing morbidity and mortality. Most of the commonly used individual screening tests offered in gener - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Vitamin D supplementation during pregnancy may be needed to protect against adverse pregnancy outcomes. This is an update of a review that was first published in 2012 and then in 2016. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
The unanticipated difficult airway is a potentially life-threatening event during anaesthesia or acute conditions. An unsuccessfully managed upper airway is associated with serious morbidity and mortality. Several bedside screening tests are used in clini - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Nutritional support is an essential component of critical care. Malnutrition has been associated with poor outcomes among patients in intensive care units (ICUs). Evidence suggests that in patients with a functional gut, nutrition should be administered t - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Autism spectrum disorders (ASD) include autistic disorder, Asperger's disorder and pervasive developmental disorder - not otherwise specified (PDD-NOS). Antipsychotics have been used as a medication intervention for irritability related to ASD. Aripiprazo - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Autism spectrum disorder (ASD) is a behaviourally diagnosed condition. It is defined by impairments in social communication or the presence of restricted or repetitive behaviours, or both. Diagnosis is made according to existing classification systems. In - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Neurocysticercosis is the most common parasitic infection of the brain. Epilepsy is the most common clinical presentation, though it may also present with headache, symptoms of raised intracranial pressure, hydrocephalus and ocular symptoms depending upon - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
People with febrile neutropaenia are usually treated in a hospital setting. Recently, treatment with oral antibiotics has been proven to be as effective as intravenous therapy. However, the efficacy and safety of outpatient treatment have not been fully e - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
District managers are playing an increasingly important role in determining the performance of health systems in low- and middle-income countries as a result of decentralization.
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