- Epidermal growth factor receptor (EGFR) inhibitors for metastatic colorectal cancer
Cochrane Systematic Reviews, 4-Jul-2017
Epidermal growth factor receptor (EGFR) inhibitors prevent cell growth and have shown benefit in the treatment of metastatic colorectal cancer, whether used as single agents or in combination with chemotherapy. Clear benefit has been shown in trials of EG - Epidermal growth factor receptor blockers for the treatment of ovarian cancer
Cochrane Systematic Reviews, 5-Dec-2018
This is an update of a previously published version of the review (Issue 10, 2011). - Epidural analgesia for adults undergoing cardiac surgery with or without cardiopulmonary bypass
Cochrane Systematic Reviews, 28-Feb-2019
General anaesthesia combined with epidural analgesia may have a beneficial effect on clinical outcomes. However, use of epidural analgesia for cardiac surgery is controversial due to a theoretical increased risk of epidural haematoma associated with syste - Epidural analgesia for pain relief following hip or knee replacement
Cochrane Systematic Reviews, 30-Jan-2014
Hip and knee replacement are common operative procedures to improve mobility and quality of life. Adequate pain relief is essential in the postoperative period to enable ambulation and initiation of physiotherapy. Lumbar epidural analgesia is a common mod - Epidural analgesia versus patient‐controlled intravenous analgesia for pain following intra‐abdominal surgery in adults
Cochrane Systematic Reviews, 4-Oct-2018
Intravenous patient-controlled analgesia (IVPCA) with opioids and epidural analgesia (EA) using either continuous epidural administration (CEA) or patient-controlled (PCEA) techniques are popular approaches for analgesia following intra-abdominal surgery. - Epidural blood patching for preventing and treating post-dural puncture headache
Cochrane Systematic Reviews, 22-Nov-2013
This is an update of a Cochrane Review first published in Issue 2, 2002. Dural puncture is a common procedure, but leakage of cerebrospinal fluid (CSF) from the resulting dural defect may cause post-dural puncture headache (PDPH) after the procedure, and - Epidural corticosteroid injections for lumbosacral radicular pain
Cochrane Systematic Reviews, 7-Apr-2020
Lumbosacral radicular pain (commonly called sciatica) is a syndrome involving patients who report radiating leg pain. Epidural corticosteroid injections deliver a corticosteroid dose into the epidural space, with the aim of reducing the local inflammatory - Epidural local anaesthetics versus opioid‐based analgesic regimens for postoperative gastrointestinal paralysis, vomiting and pain after abdominal surgery
Cochrane Systematic Reviews, 3-Jan-2017
Gastrointestinal paralysis, nausea and vomiting and pain are major clinical problems following abdominal surgery. Anaesthetic and analgesic techniques that reduce pain and postoperative nausea and vomiting (PONV), while preventing or reducing postoperativ - Epidural pain relief versus systemic opioid‐based pain relief for abdominal aortic surgery
Cochrane Systematic Reviews, 27-Mar-2017
Epidural analgesia offers greater pain relief compared to systemic opioid-based medications, but its effect on morbidity and mortality is unclear. This review was originally published in 2006 and was updated in 2012 and again in 2016. - Epidural therapy for the treatment of severe pre‐eclampsia in non labouring women
Cochrane Systematic Reviews, 27-Nov-2017
Pre-eclampsia is a pregnancy-specific multi-organ disorder, which is characterised by hypertension and multisystem organ involvement and which has significant maternal and fetal morbidity and mortality. Failure of the placental vascular remodelling and re - Epidural versus non‐epidural or no analgesia for pain management in labour
Cochrane Systematic Reviews, 18-May-2018
Epidural analgesia is a central nerve block technique achieved by injection of a local anaesthetic close to the nerves that transmit pain, and is widely used as a form of pain relief in labour. However, there are concerns about unintended adverse effects - Epilepsy clinics versus general neurology or medical clinics
Cochrane Systematic Reviews, 25-Oct-2008
Epilepsy is the most common serious neurological condition after stroke, with a 0.5% prevalence, and a two to three per cent life time risk of being given a diagnosis of epilepsy in the developed world. - Epinephrine for bronchiolitis
Cochrane Systematic Reviews, 2-May-2011
Bronchodilators are commonly used for acute bronchiolitis, despite uncertain effectiveness. - Epinephrine for the resuscitation of apparently stillborn or extremely bradycardic newborn infants
Cochrane Systematic Reviews, 17-Jan-2011
Epinephrine is a cardiac stimulant with complex effects on the heart and blood vessels. It has been used for decades in all age groups to treat cardiac arrest and bradycardia. Despite formal guidelines for the use of epinephrine in neonatal resuscitation, - Epinephrine for transient tachypnea of the newborn
Cochrane Systematic Reviews, 20-May-2016
Transient tachypnea of the newborn is characterized by tachypnea and signs of respiratory distress. Transient tachypnea typically appears within the first two hours of life in term and late preterm newborns. Although transient tachypnea of the newborn is - Epinephrine injection versus epinephrine injection and a second endoscopic method in high-risk bleeding ulcers
Cochrane Systematic Reviews, 9-Oct-2014
Endoscopic therapy reduces the rebleeding rate and the need for surgery in patients with bleeding peptic ulcers. - Eplerenone for hypertension
Cochrane Systematic Reviews, 27-Feb-2017
Eplerenone is an aldosterone receptor blocker that is chemically derived from spironolactone. In Canada, it is indicated for use as adjunctive therapy to reduce mortality for heart failure patients with New York Heart Association (NYHA) class II systolic - Equivalent schedules of intradermal fractional dose versus intramuscular full dose of inactivated polio vaccine for prevention of poliomyelitis
Cochrane Systematic Reviews, 19-Dec-2019
Poliomyelitis is a debilitating and deadly infection. Despite exponential growth in medical science, there is still no cure for the disease, which is caused by three types of wild polioviruses: types 1, 2, and 3. According to the Global Polio Eradication - Eradication therapy for Burkholderia cepacia complex in people with cystic fibrosis
Cochrane Systematic Reviews, 15-Apr-2019
Chronic infection with Burkholderia cepacia complex species remains a significant problem for clinicians treating people with cystic fibrosis. Colonisation with Burkholderia cepacia complex species is linked to a more rapid decline in lung function and in - Eradication therapy for peptic ulcer disease in Helicobacter pylori‐positive people
Cochrane Systematic Reviews, 12-Apr-2016
Peptic ulcer disease is the cause of dyspepsia in about 10% of people. Ninety-five percent of duodenal and 70% of gastric ulcers are associated with Helicobacter pylori. Eradication of H. pylori reduces the relapse rate of ulcers but the magnitude of this
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