- Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
This is an updated version of the original Cochrane review, published in 2015. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
The presence and progression of hepatic (liver) fibrosis into cirrhosis is a prognostic variable having impact on survival in people with alcoholic liver disease. Liver biopsy, although an invasive method, is the recommended 'reference standard' for diagn - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Resin-based composite (RBC) is currently accepted as a viable material for the restoration of caries for posterior permanent teeth requiring surgical treatment. Despite the fact that the thermal conductivity of the RBC restorative material closely approxi - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Melatonin is an antioxidant with anti-inflammatory and anti-apoptotic effects. Animal studies have supported a fetal neuroprotective role for melatonin when administered maternally. It is important to assess whether melatonin, given to the mother, can red - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Neuropathic pain is a consequence of damage to the central nervous system (CNS), for example, cerebrovascular accident, multiple sclerosis or spinal cord injury, or peripheral nervous system (PNS), for example, painful diabetic neuropathy (PDN), postherpe - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Malignant pleural effusion (MPE) is a common problem for people with cancer and usually associated with considerable breathlessness. A number of treatment options are available to manage the uncontrolled accumulation of pleural fluid, including administra - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Pelvic floor muscle training (PFMT) is a first-line conservative treatment for urinary incontinence in women. Other active treatments include: physical therapies (e.g. vaginal cones); behavioural therapies (e.g. bladder training); electrical or magnetic s - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Treatment with vitamin K antagonists is associated with increased morbidity and mortality. Reversal therapy with prothrombin complex concentrate (PCC) is used increasingly and is recommended in the treatment of patients with bleeding complications underta - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Although antidepressants are often a first-line treatment for adults with moderate to severe depression, many people do not respond adequately to medication, and are said to have treatment-resistant depression (TRD). Little evidence exists to inform the m - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Recurrent miscarriage affects 1% to 3% of women of reproductive age and mostly occurs before the 10th week of gestation (and around the same gestational week in subsequent miscarriages). After a miscarriage, the chances of having another miscarriage in a - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Hip fracture is a major injury that causes significant problems for affected individuals and their family and carers. Over 40% of people with hip fracture have dementia or cognitive impairment. The outcomes of these individuals after surgery are poorer th - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Survivors of critical illness often experience a multitude of problems that begin in the intensive care unit (ICU) or present and continue after discharge. These can include muscle weakness, cognitive impairments, psychological difficulties, reduced physi - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Revascularisation is the gold standard therapy for patients with critical limb ischaemia (CLI). In over 30% of patients who are not suitable for or have failed previous revascularisation therapy (the 'no-option' CLI patients), limb amputation is eventuall - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
People with coronary heart disease (CHD) often require prolonged absences from work to convalesce after acute disease events like myocardial infarctions (MI) or revascularisation procedures such as coronary artery bypass grafting (CABG) or percutaneous co - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
The association between dietary antioxidants and asthma or exercise-induced bronchoconstriction (EIB) is not fully understood. Vitamin C and vitamin E are natural antioxidants that are predominantly present in fruits and vegetables; inadequate vitamin E i - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Primary spontaneous pneumothorax is widely managed according to size with interventional techniques based on practice guidelines. Interventional management is not without complications and observational data suggest conservative management works. The curr - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
The final adult height of untreated girls aged up to 18 years with Turner syndrome (TS) is approximately 20 cm shorter compared with healthy females. Treatment with growth hormone (GH) increases the adult height of people with TS. The effects of adding th - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Early childhood vaccination is an essential global public health practice that saves two to three million lives each year, but many children do not receive all the recommended vaccines. To achieve and maintain appropriate coverage rates, vaccination progr - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Although lifestyle interventions are commonly recommended in the management of patients with chronic gout, the evidence from trial data for their benefits and safety has not been previously examined in a systematic review. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Atopic dermatitis (AD) (or atopic eczema) is a chronic inflammatory skin condition that affects children and adults and has an important impact on quality of life. Topical corticosteroids (TCS) are the first-line therapy for this condition; however, they
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