- Environmental interventions to reduce the consumption of sugar‐sweetened beverages and their effects on health
Cochrane Systematic Reviews, 29-May-2019
Frequent consumption of excess amounts of sugar-sweetened beverages (SSB) is a risk factor for obesity, type 2 diabetes, cardiovascular disease and dental caries. Environmental interventions, i.e. interventions that alter the physical or social environmen - Environmental sanitary interventions for preventing active trachoma
Cochrane Systematic Reviews, 10-Jan-2012
Trachoma is a major cause of avoidable blindness. It is responsible for about six million blind people worldwide, mostly in the poor communities of developing countries. One of the major strategies advocated for the control of the disease is the applicati - Enzyme replacement and substrate reduction therapy for Gaucher disease
Cochrane Systematic Reviews, 13-Apr-2015
Gaucher disease, a rare disorder, is caused by inherited deficiency of the enzyme glucocerebrosidase. It is unique among the ultra-orphan disorders in that four treatments are currently approved by various regulatory authorities for use in routine clinica - Enzyme replacement therapy for Anderson‐Fabry disease
Cochrane Systematic Reviews, 29-Jun-2017
Anderson-Fabry disease is an X-linked defect of glycosphingolipid metabolism. Progressive renal insufficiency is a major source of morbidity, additional complications result from cardio- and cerebro-vascular involvement. Survival is reduced among affected - Enzyme replacement therapy for infantile-onset Pompe disease
Cochrane Systematic Reviews, 14-Dec-2017
Infantile-onset Pompe disease is a rare and progressive autosomal-recessive disorder caused by a deficiency of the lysosomal enzyme acid alpha-glucosidase (GAA). Current treatment involves enzyme replacement therapy (with recombinant human alglucosidase a - Enzyme replacement therapy with galsulfase for mucopolysaccharidosis type VI
Cochrane Systematic Reviews, 25-Feb-2016
Mucopolysaccharidosis type VI or Maroteaux-Lamy syndrome is a rare genetic disorder caused by the deficiency of arylsulphatase B. The resultant accumulation of dermatan sulphate causes lysosomal damage. - Enzyme replacement therapy with idursulfase for mucopolysaccharidosis type II (Hunter syndrome)
Cochrane Systematic Reviews, 3-Feb-2016
Mucopolysaccharidosis II, also known as Hunter syndrome, is a rare, X-linked disease caused by a deficiency of the lysosomal enzyme iduronate-2-sulfatase, which catalyses a step in the catabolism of glycosaminoglycans. The glycosaminoglycans accumulate wi - Enzyme replacement therapy with laronidase (Aldurazyme®) for treating mucopolysaccharidosis type I
Cochrane Systematic Reviews, 18-Jun-2019
Mucopolysaccharidosis type I can be classified as three clinical sub-types; Hurler syndrome, Hurler-Scheie syndrome and Scheie syndrome, with the scale of severity being such that Hurler syndrome is the most severe and Scheie syndrome the least severe. It - Ephedrine for myasthenia gravis, neonatal myasthenia and the congenital myasthenic syndromes
Cochrane Systematic Reviews, 12-Dec-2014
Myasthenia is a condition in which neuromuscular transmission is affected by antibodies against neuromuscular junction components (autoimmune myasthenia gravis, MG; and neonatal myasthenia gravis, NMG) or by defects in genes for neuromuscular junction pro - Epidermal growth factor receptor (EGFR) inhibitors for metastatic colorectal cancer
Cochrane Systematic Reviews, 4-Jul-2017
Epidermal growth factor receptor (EGFR) inhibitors prevent cell growth and have shown benefit in the treatment of metastatic colorectal cancer, whether used as single agents or in combination with chemotherapy. Clear benefit has been shown in trials of EG - Epidermal growth factor receptor blockers for the treatment of ovarian cancer
Cochrane Systematic Reviews, 5-Dec-2018
This is an update of a previously published version of the review (Issue 10, 2011). - Epidural analgesia for adults undergoing cardiac surgery with or without cardiopulmonary bypass
Cochrane Systematic Reviews, 28-Feb-2019
General anaesthesia combined with epidural analgesia may have a beneficial effect on clinical outcomes. However, use of epidural analgesia for cardiac surgery is controversial due to a theoretical increased risk of epidural haematoma associated with syste - Epidural analgesia for pain relief following hip or knee replacement
Cochrane Systematic Reviews, 30-Jan-2014
Hip and knee replacement are common operative procedures to improve mobility and quality of life. Adequate pain relief is essential in the postoperative period to enable ambulation and initiation of physiotherapy. Lumbar epidural analgesia is a common mod - Epidural analgesia versus patient‐controlled intravenous analgesia for pain following intra‐abdominal surgery in adults
Cochrane Systematic Reviews, 4-Oct-2018
Intravenous patient-controlled analgesia (IVPCA) with opioids and epidural analgesia (EA) using either continuous epidural administration (CEA) or patient-controlled (PCEA) techniques are popular approaches for analgesia following intra-abdominal surgery. - Epidural blood patching for preventing and treating post-dural puncture headache
Cochrane Systematic Reviews, 22-Nov-2013
This is an update of a Cochrane Review first published in Issue 2, 2002. Dural puncture is a common procedure, but leakage of cerebrospinal fluid (CSF) from the resulting dural defect may cause post-dural puncture headache (PDPH) after the procedure, and - Epidural corticosteroid injections for lumbosacral radicular pain
Cochrane Systematic Reviews, 7-Apr-2020
Lumbosacral radicular pain (commonly called sciatica) is a syndrome involving patients who report radiating leg pain. Epidural corticosteroid injections deliver a corticosteroid dose into the epidural space, with the aim of reducing the local inflammatory - Epidural local anaesthetics versus opioid‐based analgesic regimens for postoperative gastrointestinal paralysis, vomiting and pain after abdominal surgery
Cochrane Systematic Reviews, 3-Jan-2017
Gastrointestinal paralysis, nausea and vomiting and pain are major clinical problems following abdominal surgery. Anaesthetic and analgesic techniques that reduce pain and postoperative nausea and vomiting (PONV), while preventing or reducing postoperativ - Epidural pain relief versus systemic opioid‐based pain relief for abdominal aortic surgery
Cochrane Systematic Reviews, 27-Mar-2017
Epidural analgesia offers greater pain relief compared to systemic opioid-based medications, but its effect on morbidity and mortality is unclear. This review was originally published in 2006 and was updated in 2012 and again in 2016. - Epidural therapy for the treatment of severe pre-eclampsia in non labouring women
Cochrane Systematic Reviews, 28-Nov-2017
Pre-eclampsia is a pregnancy-specific multi-organ disorder, which is characterised by hypertension and multisystem organ involvement and which has significant maternal and fetal morbidity and mortality. Failure of the placental vascular remodelling and re - Epidural versus non‐epidural or no analgesia for pain management in labour
Cochrane Systematic Reviews, 18-May-2018
Epidural analgesia is a central nerve block technique achieved by injection of a local anaesthetic close to the nerves that transmit pain, and is widely used as a form of pain relief in labour. However, there are concerns about unintended adverse effects
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