- Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Liver transplantation is an established treatment option for end-stage liver failure. Now that newer, more potent immunosuppressants have been developed, glucocorticosteroids may no longer be needed and their removal may prevent adverse effects. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
This is an updated version of the original Cochrane review published in Issue 3 (Lee 2012) on patient positioning (mobilisation) and bracing for pain relief and spinal stability in adults with metastatic spinal cord compression. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Ulceration of the feet, which can lead to the amputation of feet and legs, is a major problem for people with diabetes mellitus, and can cause substantial economic burden. Single preventive strategies have not been shown to reduce the incidence of foot ul - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Hepatocellular carcinoma is the most common primary malignant cancer of the liver. Evidence for the role of cryotherapy in the treatment of hepatocellular carcinoma is controversial. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Stavudine remains a component of combination antiretroviral therapy (ART) in resource-constrained countries due to its relatively low cost despite the WHO recommendation for its phasing out as a strategy to reduce stavudine associated toxicities. Where st - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Dietary fluoride supplements were first introduced to provide systemic fluoride in areas where water fluoridation is not available. Since 1990, the use of fluoride supplements in caries prevention has been re-evaluated in several countries. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Repeated use of postcoital hormonal contraception is not currently recommended due to the higher risk of side effects and lower contraceptive effectiveness compared to other modern methods of contraception. However, emerging evidence indicates renewed int - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Anaphylaxis is a serious hypersensitivity reaction that is rapid in onset and may result in death. Anaphylaxis guidelines recommend glucocorticoids for the treatment of people experiencing anaphylaxis. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Early neonatal hyperglycemia is common among very low birth weight (VLBW) neonates. Increased risks for death and major morbidities have been observed among VLBW neonates who develop hyperglycemia. It is uncertain whether the hyperglycemia per se is a cau - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Topical corticosteroids are the most frequently prescribed dermatological treatment and are often used by pregnant women with skin conditions. However, little is known about their safety in pregnancy. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Crohn's disease is a chronic relapsing condition of the alimentary tract with a high morbidity secondary to bowel inflammation. Glutamine plays a key role in maintaining the integrity of the intestinal mucosa and has been shown to reduce inflammation and - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Crohn's disease is a chronic relapsing condition of the alimentary tract with a high morbidity secondary to bowel inflammation. High levels of tumour necrosis factor-alpha (TNF-a) have been associated with the development of intestinal inflammation in Cro - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Maintenance of remission is a major issue in the management of Crohn's disease. Thalidomide, a tumour necrosis factor-alpha (TNF-a) inhibitor and its analogue, lenalidomide, may have a role in the management of Crohn's disease, but it is not clear whether - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Impaction of a soft food bolus in the oesophagus causes dysphagia and regurgitation. If the bolus does not pass spontaneously, then the patient is at risk of aspiration, dehydration, perforation, and death. Definitive management is with endoscopic interve - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
The myelodysplastic syndrome (MDS) comprises a diverse group of haematopoietic stem cell disorders. Due to symptomatic anaemia, most people with MDS require supportive therapy including repeated red blood cell (RBC) transfusions. In combination with incre - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
The risk of maternal mortality and morbidity is higher after caesarean section than for vaginal birth. With increasing rates of caesarean section, it is important to minimise risks to the mother as much as possible. This review focused on different skin p - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Tinnitus is described as the perception of sound or noise in the absence of real acoustic stimulation. Although an outright cure for tinnitus remains elusive, various management strategies have been developed to help to lessen the impact of the symptom. F - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Osteoarthritis is the most common form of joint disease and the leading cause of pain and disability in the elderly. S-Adenosylmethionine may be a viable treatment option but the evidence about its effectiveness and safety is equivocal. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Osteoarthritis is a chronic joint disease that involves degeneration of articular cartilage. Pre-clinical data suggest that doxycycline might act as a disease-modifying agent for the treatment of osteoarthritis, with the potential to slow cartilage degene - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Central retinal vein occlusion (CRVO) is a common retinal vascular abnormality associated with conditions such as hypertension, diabetes, glaucoma, and a wide variety of hematologic disorders. Macular edema (ME) represents an important vision-threatening
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