- Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Osteoarthritis is the most common form of joint disease and the leading cause of pain and disability in the elderly. S-Adenosylmethionine may be a viable treatment option but the evidence about its effectiveness and safety is equivocal. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Osteoarthritis is a chronic joint disease that involves degeneration of articular cartilage. Pre-clinical data suggest that doxycycline might act as a disease-modifying agent for the treatment of osteoarthritis, with the potential to slow cartilage degene - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Central retinal vein occlusion (CRVO) is a common retinal vascular abnormality associated with conditions such as hypertension, diabetes, glaucoma, and a wide variety of hematologic disorders. Macular edema (ME) represents an important vision-threatening - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Arthritis remains a relatively infrequent complication of cystic fibrosis, but is a cause of significant morbidity when it does occur. Two distinct types of arthritis are described in cystic fibrosis: cystic fibrosis-related arthropathy and hypertrophic o - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Crohn's disease is a chronic relapsing condition of the alimentary tract with a high morbidity secondary to bowel inflammation. High levels of tumour necrosis factor-alpha (TNF-a) have been associated with the development of intestinal inflammation in Cro - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Maintenance of remission is a major issue in the management of Crohn's disease. Thalidomide, a tumour necrosis factor-alpha (TNF-a) inhibitor and its analogue, lenalidomide, may have a role in the management of Crohn's disease, but it is not clear whether - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Impaction of a soft food bolus in the oesophagus causes dysphagia and regurgitation. If the bolus does not pass spontaneously, then the patient is at risk of aspiration, dehydration, perforation, and death. Definitive management is with endoscopic interve - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Infection with human immunodeficency virus (HIV) and acquired immunodeficency syndrome (AIDS) is a pandemic that has affected millions of people globally. Although major research and clinical initiatives are addressing prevention and cure strategies, issu - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Topical corticosteroids are the most frequently prescribed dermatological treatment and are often used by pregnant women with skin conditions. However, little is known about their safety in pregnancy. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Crohn's disease is a chronic relapsing condition of the alimentary tract with a high morbidity secondary to bowel inflammation. Glutamine plays a key role in maintaining the integrity of the intestinal mucosa and has been shown to reduce inflammation and - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Blood loss during liver resection is considered one of the most important factors affecting the peri-operative outcomes of patients undergoing liver resection. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Alcoholic hepatitis is a life-threatening disease, with an average mortality of approximately 40%. There is no widely accepted, effective treatment for alcoholic hepatitis. Pentoxifylline is used to treat alcoholic hepatitis, but there has been no systema - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Nonalcoholic fatty liver disease (NAFLD) is increasingly recognised as a condition associated with overweight or obesity that may progress to end-stage liver disease. NAFLD histology resembles alcohol-induced liver injury, but occurs in patients with no h - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Leptospira infection is a global zoonosis with significant health impact for agricultural workers and those persons whose work or recreation takes them into endemic areas. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Acute intestinal obstruction is one of the most common surgical emergencies. The small bowel obstruction (SBO) is the site of obstruction in most patients (76%) and adhesions are the most common etiology (65%). Laparoscopy in SBO has no clear role yet as - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Anxiety disorders are a potentially disabling group of disorders that frequently co-occur with alcohol use disorders. Comorbid anxiety and alcohol use disorders are associated with poorer outcomes, and are difficult to treat with standard psychosocial int - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Pancreatic cancer causes severe pain in 50 to 70% of patients and is often difficult to treat. Celiac plexus block (CPB) is thought to be a safe and effective technique for reducing the severity of pain. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Circuit class therapy (CCT) offers a supervised group forum for people after stroke to practise tasks, enabling increased practice time without increasing staffing. This is an update of the original review published in 2010. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Chronic neutrophilic inflammation, in both the presence and absence of infection, is a feature of bronchiectasis in adults and children. The anti-inflammatory properties of non-steroid anti-inflammatory drugs (NSAIDs) may be beneficial in reducing airway - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Abnormal blood flow patterns in fetal circulation detected by Doppler ultrasound may indicate poor fetal prognosis. It is also possible that false positive Doppler ultrasound findings could lead to adverse outcomes from unnecessary interventions, includin
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