- Effects of all‐trans retinoic acid (ATRA) in addition to chemotherapy for adults with acute myeloid leukaemia (AML) (non‐acute promyelocytic leukaemia (non‐APL))
Cochrane Systematic Reviews, 26-Jul-2018
Acute myeloid leukaemia (AML) is the most common acute leukaemia affecting adults. Most patients diagnosed with AML are at advanced age and present with co-morbidities, so that intensive therapy such as stem cell transplantation (SCT) is impossible to pro - Effects of changes in the pre‐licensure education of health workers on health‐worker supply
Cochrane Systematic Reviews, 15-Feb-2009
The current and projected crisis because of a shortage of health workers in low and middle-income countries (LMICs) requires that effective strategies for expanding the numbers of health workers are quickly identified in order to inform action by policyma - Effects of communicating DNA-based disease risk estimates on risk-reducing behaviours
Cochrane Systematic Reviews, 7-Sep-2010
There are high expectations regarding the potential for the communication of DNA-based disease risk estimates to motivate behaviour change. - Effects of consumers and health providers working in partnership on health services planning, delivery and evaluation
Cochrane Systematic Reviews,
Health services have traditionally been developed to focus on specific diseases or medical specialties. Involving consumers as partners in planning, delivering and evaluating health services may lead to services that are person-centred and so better able - Effects of glucocorticoids on radiological progression in rheumatoid arthritis
Cochrane Systematic Reviews, 16-Sep-2008
Glucocorticoid use in rheumatoid arthritis (RA) is widespread. Two Cochrane Reviews have been published examining the short term clinical benefit of low dose glucocorticoids compared to non-steroidal anti-inflammatory drugs and demonstrate good short term - Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride
Cochrane Systematic Reviews,
Recent cohort studies show that salt intake below 6 g is associated with increased mortality. These findings have not changed public recommendations to lower salt intake below 6 g, which are based on assumed blood pressure (BP) effects and no side-effects - Effects of nonsteroidal anti‐inflammatory drugs on postoperative renal function in adults with normal renal function
Cochrane Systematic Reviews, 5-Dec-2018
Nonsteroidal anti-inflammatory drugs (NSAIDs) can play a major role in the management of acute pain in the peri-operative period. However, there are conflicting views on whether NSAIDs are associated with adverse renal effects. - Effects of opioid, hypnotic and sedating medications on sleep‐disordered breathing in adults with obstructive sleep apnoea
Cochrane Systematic Reviews, 8-Jul-2015
Obstructive sleep apnoea (OSA) is a common sleep disorder characterised by partial or complete upper airway occlusion during sleep, leading to intermittent cessation (apnoea) or reduction (hypopnoea) of airflow and dips in arterial oxygen saturation durin - Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years of age
Cochrane Systematic Reviews,
Vitamin D is a secosteroid hormone that is important for its role in calcium homeostasis to maintain skeletal health. Linear growth faltering and stunting remain pervasive indicators of poor nutrition status among infants and children under five years of - Effects of peri‐operative nonsteroidal anti‐inflammatory drugs on post‐operative kidney function for adults with normal kidney function
Cochrane Systematic Reviews, 28-Nov-2018
Nonsteroidal anti-inflammatory drugs (NSAIDs) provide effective analgesia during the post-operative period but can cause acute kidney injury (AKI) when used peri-operatively (at or around the time of surgery). This is an update of a Cochrane review publis - Effects of restricted caffeine intake by mother on fetal, neonatal and pregnancy outcomes
Cochrane Systematic Reviews, 1-Jun-2015
Maternal caffeine consumption during pregnancy may have adverse effects on fetal, neonatal and maternal outcomes. - Effects of sevoflurane versus other general anaesthesia on emergence agitation in children
Cochrane Systematic Reviews, 9-Sep-2014
Sevoflurane is an inhaled volatile anaesthetic that is widely used in paediatric anaesthetic practice. Since its introduction, postoperative behavioural disturbance known as emergence agitation (EA) or emergence delirium (ED) has been recognized as a prob - Effects of targeting lower versus higher arterial oxygen saturations on death or disability in preterm infants
Cochrane Systematic Reviews, 21-Feb-2018
The use of supplemental oxygen in the care of extremely preterm infants has been common practice since the 1940s. Despite this, there is little agreement regarding which oxygen saturation (SpO2) ranges to target to maximise short- or long-term growth and - Effects of total fat intake on body fatness in adults
Cochrane Systematic Reviews,
The ideal proportion of energy from fat in our food and its relation to body weight is not clear. In order to prevent overweight and obesity in the general population, we need to understand the relationship between the proportion of energy from fat and re - Effects of total fat intake on body weight
Cochrane Systematic Reviews, 19-Aug-2016
In order to prevent overweight and obesity in the general population we need to understand the relationship between the proportion of energy from fat and resulting weight and body fatness in the general population. - Effects of total fat intake on bodyweight in children
Cochrane Systematic Reviews, 3-Jul-2018
As part of efforts to prevent childhood overweight and obesity, we need to understand the relationship between total fat intake and body fatness in generally healthy children. - Efficacy and experiences of telephone counselling for informal carers of people with dementia
Cochrane Systematic Reviews, 22-Aug-2014
Informal carers of people with dementia can suffer from depressive symptoms, emotional distress and other physiological, social and financial consequences. - Efficacy and safety of ablation for people with non-paroxysmal atrial fibrillation
Cochrane Systematic Reviews, 18-Nov-2016
The optimal rhythm management strategy for people with non-paroxysmal (persistent or long-standing persistent) atrial fibrilation is currently not well defined. Antiarrhythmic drugs have been the mainstay of therapy. But recently, in people who have not r - Efficacy and safety of cesarean delivery for prevention of mother‐to‐child transmission of HIV‐1
Cochrane Systematic Reviews, 15-Mar-2011
Cesarean section before labor and before ruptured membranes ("elective cesarean section", or ECS) has been introduced as an intervention for the prevention of mother-to-child transmission (MTCT) of HIV-1. The role of mode of delivery in the management of - Efficacy and safety of pharmacological interventions for the treatment of the Alcohol Withdrawal Syndrome
Cochrane Systematic Reviews, 3-May-2011
Alcohol abuse and dependence represents a very serious health problem worldwide with major social, interpersonal and legal interpolations. Pharmacological treatments presently used are of uncertain effectiveness and there is even more doubt on the compara
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