- Early versus delayed antiretroviral treatment in HIV‐positive people with cryptococcal meningitis
Cochrane Systematic Reviews, 24-Jul-2018
There remains uncertainty about the optimum timing of antiretroviral therapy (ART) initiation in HIV-positive people with cryptococcal meningitis. This uncertainty is the result of conflicting data on the mortality risk and occurrence of immune reconstitu - Early versus delayed appendicectomy for appendiceal phlegmon or abscess
Cochrane Systematic Reviews, 2-Jun-2017
Appendiceal phlegmon and abscess account for 2% to 10% of acute appendicitis. People with appendiceal phlegmon or abscess usually need an appendicectomy to relieve their symptoms and avoid complications. The timing of appendicectomy for appendiceal phlegm - Early versus delayed continuous positive airway pressure (CPAP) for respiratory distress in preterm infants
Cochrane Systematic Reviews, 15-Oct-2020
The application of continuous positive airway pressure (CPAP) has been shown to have some benefits in the treatment of preterm infants with respiratory distress. CPAP has the potential to reduce lung damage, particularly if applied early before atelectasi - Early versus delayed dressing removal after primary closure of clean and clean‐contaminated surgical wounds
Cochrane Systematic Reviews, 3-Sep-2015
Most surgical procedures involve a cut in the skin that allows the surgeon to gain access to the deeper tissues or organs. Most surgical wounds are closed fully at the end of the procedure (primary closure). The surgeon covers the closed surgical wound wi - Early versus delayed enteral nutrition support for burn injuries
Cochrane Systematic Reviews, 19-Oct-2008
A burn injury increases the body's metabolic demands, and therefore nutritional requirements. Provision of an adequate supply of nutrients is believed to lower the incidence of metabolic abnormalities, thus reducing septic morbidity, improving survival ra - Early versus delayed erythropoietin for the anaemia of end‐stage kidney disease
Cochrane Systematic Reviews, 16-Dec-2015
Anaemia is a common complication in people with chronic kidney disease (CKD) and mainly develops as a consequence of relative erythropoietin (EPO) deficiency. Anaemia develops early in the course of disease and peaks among people with end-stage kidney dis - Early versus delayed laparoscopic cholecystectomy for acute gallstone pancreatitis
Cochrane Systematic Reviews, 28-Aug-2013
Gallstones and alcohol account for more than 80% of acute pancreatitis. Cholecystectomy is the definitive treatment for gallstones. Laparoscopic cholecystectomy is the preferred route for performing cholecystectomy. The timing of laparoscopic cholecystect - Early versus delayed laparoscopic cholecystectomy for people with acute cholecystitis
Cochrane Systematic Reviews, 30-Jun-2013
Gallstones are present in about 10% to 15% of the adult western population. Between 1% and 4% of these adults become symptomatic in a year (the majority due to biliary colic but a significant proportion due to acute cholecystitis). Laparoscopic cholecyste - Early versus delayed laparoscopic cholecystectomy for uncomplicated biliary colic
Cochrane Systematic Reviews, 26-Jun-2013
Uncomplicated biliary colic is one of the commonest indications for laparoscopic cholecystectomy. Laparoscopic cholecystectomy involves several months of waiting if performed electively. However, people can develop life-threatening complications during th - Early versus delayed mobilisation for aneurysmal subarachnoid haemorrhage
Cochrane Systematic Reviews, 9-Apr-2013
Rebleeding is an important cause of death and disability in patients with aneurysmal subarachnoid haemorrhage (SAH). In order to prevent rebleeding, the preferred strategy is aneurysm ablation (removal) as early as possible. However, in clinical practice - Early versus delayed oral fluids and food for reducing complications after major abdominal gynaecologic surgery
Cochrane Systematic Reviews, 12-Dec-2014
This is an updated version of the original Cochrane review published in 2007. Traditionally, after major abdominal gynaecologic surgery postoperative oral intake is withheld until the return of bowel function. There has been concern that early oral intake - Early versus delayed post‐operative bathing or showering to prevent wound complications
Cochrane Systematic Reviews, 23-Jul-2015
Many people undergo surgical operations during their life-time, which result in surgical wounds. After an operation the incision is closed using stiches, staples, steri-strips or an adhesive glue. Usually, towards the end of the surgical procedure and bef - Early versus delayed postoperative radiotherapy for treatment of low‐grade gliomas
Cochrane Systematic Reviews, 20-Jan-2020
This is an update of the review originally published in 2011 and first updated in 2015. - Early versus Delayed Refeeding for Children with Acute Diarrhoea
Cochrane Systematic Reviews, 6-Jul-2011
Acute diarrhoea is one of the principal causes of morbidity and mortality among children in low-income countries. The cornerstone of treatment is oral rehydration therapy and dietary management. However, there is a lack of data and studies on both the t - Early versus delayed selective surfactant treatment for neonatal respiratory distress syndrome
Cochrane Systematic Reviews, 14-Nov-2012
Clinical trials have confirmed that surfactant therapy is effective in improving the immediate need for respiratory support and the clinical outcome of premature newborns. Trials have studied a wide variety of surfactant preparations used either to preven - Early versus late administration of amino acids in preterm infants receiving parenteral nutrition
Cochrane Systematic Reviews, 23-Jul-2013
Observational studies in preterm newborns suggest that delay in administering amino acids could result in a protein catabolic state and could impact on growth and development. - Early versus late antiepileptic drug withdrawal for people with epilepsy in remission
Cochrane Systematic Reviews, 12-Feb-2015
Epilepsy is a chronic neurological disorder which affects millions of people around the world. Antiepileptic drugs (AED) are the main interventions used to prevent seizures and control epilepsy. Although effective in most cases, AEDs are related to long-t - Early versus late chest radiotherapy in patients with limited‐stage small cell lung cancer
Cochrane Systematic Reviews, 18-Oct-2004
This is an update of the original review published in Issue 1, 2005. It is standard clinical practice to combine chemotherapy and chest radiotherapy in treating patients with limited-stage small cell lung cancer. However, the best way to integrate both mo - Early versus late discontinuation of oxygen in preterm or low birth weight infants
Cochrane Systematic Reviews, 23-Oct-2001
It has been hypothesized that the duration of supplemental oxygen administration, independent of the oxygen concentration, gestational age and/or birth weight, is influential in the development of severe retinopathy of prematurity (ROP). Concern regarding - Early versus late erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants
Cochrane Systematic Reviews, 11-Feb-2020
Low plasma levels of erythropoietin (EPO) in preterm infants provide a rationale for the use of EPO to prevent or treat anaemia.
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