- Early versus late administration of amino acids in preterm infants receiving parenteral nutrition
Cochrane Systematic Reviews, 23-Jul-2013
Observational studies in preterm newborns suggest that delay in administering amino acids could result in a protein catabolic state and could impact on growth and development. - Early versus late antiepileptic drug withdrawal for people with epilepsy in remission
Cochrane Systematic Reviews, 29-Apr-2015
Epilepsy is a chronic neurological disorder which affects millions of people around the world. Antiepileptic drugs (AED) are the main interventions used to prevent seizures and control epilepsy. Although effective in most cases, AEDs are related to long-t - Early versus late chest radiotherapy in patients with limited-stage small cell lung cancer
Cochrane Systematic Reviews, 8-Nov-2010
This is an update of the original review published in Issue 1, 2005. It is standard clinical practice to combine chemotherapy and chest radiotherapy in treating patients with limited-stage small cell lung cancer. However, the best way to integrate both mo - Early versus late discontinuation of oxygen in preterm or low birth weight infants
Cochrane Systematic Reviews, 12-Aug-2009
It has been hypothesized that the duration of supplemental oxygen administration, independent of the oxygen concentration, gestational age and/or birth weight, is influential in the development of severe retinopathy of prematurity (ROP). Concern regarding - Early versus late erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants
Cochrane Systematic Reviews, 27-Jan-2020
Low plasma levels of erythropoietin (EPO) in preterm infants provide a rationale for the use of EPO to prevent or treat anaemia. - Early versus late initiation of epidural analgesia for labour
Cochrane Systematic Reviews, 1-Oct-2014
Pain during childbirth is arguably the most severe pain some women may experience in their lifetime. Epidural analgesia is an effective form of pain relief during labour. Many women have concerns regarding its safety. Furthermore, epidural services and an - Early versus late parenteral nutrition for critically ill term and late preterm infants
Cochrane Systematic Reviews, 6-Apr-2020
Recently conducted randomised controlled trials (RCTs) suggest that late commencement of parenteral nutrition (PN) may have clinical benefits in critically ill adults and children. However, there is currently limited evidence regarding the optimal timing - Early versus late pre‐intensive care unit admission broad spectrum antibiotics for severe sepsis in adults
Cochrane Systematic Reviews, 14-Dec-2018
Severe sepsis and septic shock have recently emerged as particularly acute and lethal challenges amongst critically ill patients presenting to the emergency department (ED). There are no existing data on the current practices of management of patients wit - Early versus late removal of the laryngeal mask airway (LMA) for general anaesthesia
Cochrane Systematic Reviews, 10-Aug-2015
The laryngeal mask airway (LMA) is a safe and effective modality to maintain the airway for general anaesthesia during surgical procedures. The LMA is removed at the end of surgery and anaesthesia, when the patient maintains an adequate respiratory rate a - Early versus late tracheostomy for critically ill patients
Cochrane Systematic Reviews, 14-Dec-2018
Long-term mechanical ventilation is the most common situation for which tracheostomy is indicated for patients in intensive care units (ICUs). 'Early' and 'late' tracheostomies are two categories of the timing of tracheostomy. Evidence on the advantages a - Early versus late ureteric stent removal after kidney transplantation
Cochrane Systematic Reviews, 18-Jan-2018
Kidney transplantation is the treatment of choice for patients with end-stage kidney disease. In a previous review we concluded that the routine use of ureteric stents in kidney transplantation reduces the incidence of major urological complications (MUC) - Early volume expansion for prevention of morbidity and mortality in very preterm infants
Cochrane Systematic Reviews, 12-May-2009
Reduced perfusion of organs such as the brain, heart, kidneys and the gastrointestinal tract may lead to acute dysfunction and be associated with permanent injury. Various strategies have been used to provide cardiovascular support to preterm infants incl - Early volume expansion versus inotrope for prevention of morbidity and mortality in very preterm infants
Cochrane Systematic Reviews, 6-Nov-2008
Reduced perfusion of organs such as the brain, heart, kidneys and the gastrointestinal tract may lead to acute dysfunction and be associated with permanent injury. Various strategies have been used to provide cardiovascular support to preterm infants incl - Echinacea for preventing and treating the common cold
Cochrane Systematic Reviews, 2-Jul-2014
Echinacea plant preparations (family Asteraceae) are widely used in Europe and North America for common colds. Most consumers and physicians are not aware that products available under the term Echinacea differ appreciably in their composition, mainly du - Eculizumab for treating patients with paroxysmal nocturnal hemoglobinuria
Cochrane Systematic Reviews, 30-Oct-2014
Paroxysmal nocturnal hemoglobinuria (PNH) is a chronic, not malignant, disease of the hematopoietic stem cells, associated with significant morbidity and mortality. It is a rare disease with an estimated incidence of 1.3 new cases per one million individu - Edaravone for acute intracerebral haemorrhage
Cochrane Systematic Reviews, 12-Jan-2011
Intracerebral haemorrhage (ICH) causes significant morbidity and mortality. Prognosis for ICH patients is poor. Edaravone may be safe and effective in reducing the risk of early death and improving long-term functional outcomes in survivors. - Edaravone for acute ischaemic stroke
Cochrane Systematic Reviews, 3-Oct-2011
Neuroprotection is a promising therapeutic strategy for the treatment of acute ischaemic stroke. Edaravone is a neuroprotective agent that has been widely used in China, and several studies have suggested that it may be beneficial in acute ischaemic strok - Education and training for preventing and minimizing workplace aggression directed toward healthcare workers
Cochrane Systematic Reviews,
Workplace aggression constitutes a serious issue for healthcare workers and organizations. Aggression is tied to physical and mental health issues at an individual level, as well as to absenteeism, decreased productivity or quality of work, and high emplo - Education and training for preventing sharps injuries and splash exposures in healthcare workers
Cochrane Systematic Reviews,
In healthcare settings, health care workers (HCWs) are at risk of acquiring infectious diseases through sharps injuries and splash exposures to blood or bodily fluids. Education and training interventions are widely used to protect workers' health and saf - Education for contraceptive use by women after childbirth
Cochrane Systematic Reviews, 22-Jul-2015
Contraceptive education is generally a standard component of postpartum care, although the effectiveness is seldom examined. The assumptions that form the basis of such programs include postpartum women being motivated to use contraception and that they w
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