- Drug treatment for spinal muscular atrophy types II and III
Cochrane Systematic Reviews, 6-Jan-2020
Spinal muscular atrophy (SMA) is caused by a homozygous deletion of the survival motor neuron 1 (SMN1) gene on chromosome 5, or a heterozygous deletion in combination with a (point) mutation in the second SMN1 allele. This results in degeneration of anter - Drug treatments for managing cystic fibrosis‐related diabetes
Cochrane Systematic Reviews, 19-Oct-2020
The Cystic Fibrosis Foundation recommends both short-term and long-acting insulin therapy when cystic fibrosis-related diabetes (CFRD) has been diagnosed. Diagnosis is based on: an elevated fasting blood glucose level greater than 6.94 mmol/L (125 mg/dL); - Drug‐eluting balloon angioplasty versus uncoated balloon angioplasty for peripheral arterial disease of the lower limbs
Cochrane Systematic Reviews, 4-Aug-2016
Atherosclerotic peripheral arterial disease (PAD) can lead to disabling ischemia and limb loss. Treatment modalities have included risk factor optimization through life-style modifications and medications, or operative approaches using both open and minim - Drug‐eluting balloon angioplasty versus uncoated balloon angioplasty for the treatment of in‐stent restenosis of the femoropopliteal arteries
Cochrane Systematic Reviews, 26-Jan-2019
Stents are placed in the femoropopliteal arteries for numerous reasons, such as atherosclerotic disease, the need for dissection, and perforation of the arteries, and can become stenosed with the passage of time. When a stent develops a flow-limiting sten - Drug-eluting stents versus bare metal stents for angina or acute coronary syndromes
Cochrane Systematic Reviews, 20-Oct-2015
Coronary artery stents are tiny tubular devices used to 'scaffold' vessels open during percutaneous transluminal coronary angioplasty (PTCA). Restenosis (re-narrowing) of vessels treated with stents is a problem; in order to reduce restenosis, stents that - Drug‐eluting stents versus bare‐metal stents for acute coronary syndrome
Cochrane Systematic Reviews, 23-Aug-2017
Approximately 3.7 million people died from acute coronary syndrome worldwide in 2012. Acute coronary syndrome, also known as myocardial infarction or unstable angina pectoris, is caused by a sudden blockage of the blood supplied to the heart muscle. Percu - Drugs and pacemakers for vasovagal, carotid sinus and situational syncope
Cochrane Systematic Reviews, 5-Oct-2011
Neurally mediated reflex syncope is the most common cause of transient loss of consciousness. In patients not responding to non-pharmacological treatment, pharmacological or pacemaker treatment might be considered. - Drugs for discoid lupus erythematosus
Cochrane Systematic Reviews, 5-May-2017
Discoid lupus erythematosus (DLE) is a chronic form of cutaneous lupus, which can cause scarring. Many drugs have been used to treat this disease and some (such as thalidomide, cyclophosphamide and azathioprine) are potentially toxic. This is an update of - Drugs for nocturnal enuresis in children (other than desmopressin and tricyclics)
Cochrane Systematic Reviews, 12-Dec-2012
Enuresis (bedwetting) is a socially stigmatising and stressful condition which affects around 15% to 20% of five-year olds and up to 2% of young adults. Although there is a high rate of spontaneous remission, the social, emotional and psychological costs - Drugs for preventing lung cancer in healthy people
Cochrane Systematic Reviews, 4-Mar-2020
This is the second update of this Cochrane Review. Some studies have suggested a protective effect of antioxidant nutrients and higher dietary levels of fruits and vegetables on lung cancer. - Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no treatment
Cochrane Systematic Reviews, 10-Oct-2014
Pregnancy increases the risk of malaria and this is associated with poor health outcomes for both the mother and the infant, especially during the first or second pregnancy. To reduce these effects, the World Health Organization recommends that pregnant w - Drugs for preventing migraine headaches in children
Cochrane Systematic Reviews, 10-Jun-2019
It has been estimated that about 10 per cent of children between 6 and 20 years of age suffer from migraine, and that children with migraine lose one and a half weeks more schooling per year than their peers. Prophylactic drugs can be prescribed when chil - Drugs for preventing postoperative nausea and vomiting
Cochrane Systematic Reviews, 17-Jul-2017
Drugs can prevent postoperative nausea and vomiting, but their relative efficacies and side effects have not been compared within one systematic review. - Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta‐analysis
Cochrane Systematic Reviews, 19-Oct-2020
Postoperative nausea and vomiting (PONV) is a common adverse effect of anaesthesia and surgery. Up to 80% of patients may be affected. These outcomes are a major cause of patient dissatisfaction and may lead to prolonged hospital stay and higher costs of - Drugs for preventing red blood cell dehydration in people with sickle cell disease
Cochrane Systematic Reviews, 19-Oct-2018
Sickle cell disease is an inherited disorder of hemoglobin, resulting in abnormal red blood cells. These are rigid and may block blood vessels leading to acute painful crises and other complications. Recent research has focused on therapies to rehydrate t - Drugs for preventing tuberculosis in people at risk of multiple‐drug‐resistant pulmonary tuberculosis
Cochrane Systematic Reviews, 19-Apr-2006
The emergence and spread of multiple-drug-resistant tuberculosis (MDR-TB), caused by strains of Mycobacterium tuberculosis resistant to at least isoniazid and rifampicin, is a potential threat to global tuberculosis control. Treatment is prolonged, expens - Drugs for the acute treatment of migraine in children and adolescents
Cochrane Systematic Reviews, 19-Apr-2016
Numerous medications are available for the acute treatment of migraine in adults, and some have now been approved for use in children and adolescents in the ambulatory setting. A systematic review of acute treatment of migraine medication trials in childr - Drugs for the treatment of nausea and vomiting in adults in the emergency department setting
Cochrane Systematic Reviews, 20-Dec-2018
Nausea and vomiting is a common and distressing presenting complaint in emergency departments (ED). The aetiology of nausea and vomiting in EDs is diverse and drugs are commonly prescribed. There is currently no consensus as to the optimum drug treatment - Drugs for treating Buruli ulcer (Mycobacterium ulcerans disease)
Cochrane Systematic Reviews, 23-Aug-2018
Buruli ulcer is a necrotizing cutaneous infection caused by infection with Mycobacterium ulcerans bacteria that occurs mainly in tropical and subtropical regions. The infection progresses from nodules under the skin to deep ulcers, often on the upper and - Drugs for treating giardiasis
Cochrane Systematic Reviews, 12-Nov-2012
Giardiasis infection may be asymptomatic, or can cause diarrhoea (sometimes severe), weight loss, malabsorption, and, in children, failure to thrive. It is usually treated with metronidazole given three times daily for five to 10 days.
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