- Double-bundle versus single-bundle reconstruction for anterior cruciate ligament rupture in adults
Cochrane Systematic Reviews, 3-Oct-2012
Arthroscopic reconstruction for anterior cruciate ligament rupture is a common orthopaedic procedure. One area of controversy is whether the method of double-bundle reconstruction, which represents the 'more anatomical' approach, gives improved outcomes c - Down‐titration and discontinuation strategies of tumour necrosis factor–blocking agents for rheumatoid arthritis in patients with low disease activity
Cochrane Systematic Reviews, 24-May-2019
Anti–tumour necrosis factor (TNF) agents are effective in treating people with rheumatoid arthritis (RA), but are associated with (dose-dependent) adverse effects and high costs. To prevent overtreatment, several trials have assessed the effectiveness of - Doxapram for ventilatory failure due to exacerbations of chronic obstructive pulmonary disease
Cochrane Systematic Reviews, 1-Sep-2008
COPD is a progressive illness and in the later stages, exacerbations may lead to ventilatory failure. The combination of hypoxia and hypercapnia can lead to coma and death. Correction of these blood gas abnormalities is a medical emergency. Doxapram is a - Doxapram treatment for apnea in preterm infants
Cochrane Systematic Reviews, 25-Feb-2013
Recurrent apnea is common in preterm infants, particularly at very early gestational ages. Apnea can lead to hypoxemia and bradycardia, which may be severe enough to require resuscitation including use of positive pressure ventilation. Doxapram has been u - Doxapram versus methylxanthine for apnea in preterm infants
Cochrane Systematic Reviews, 25-Feb-2013
Recurrent apnea is common in preterm infants, particularly at very early gestational ages. These episodes of loss of effective breathing can lead to hypoxemia and bradycardia which may be severe enough to require resuscitation including use of positive pr - Doxorubicin‐based chemotherapy for the palliative treatment of adult patients with locally advanced or metastatic soft tissue sarcoma
Cochrane Systematic Reviews, 21-Jul-2003
Considerable controversy exists as to whether any benefit of doxorubicin-based combination chemotherapy outweighs increased toxic effects, inconvenience, and additional costs, compared to single-agent doxorubicin. There is substantial variation in clinica - Doxycycline for osteoarthritis of the knee or hip
Cochrane Systematic Reviews, 14-Nov-2012
Osteoarthritis is a chronic joint disease that involves degeneration of articular cartilage. Pre-clinical data suggest that doxycycline might act as a disease-modifying agent for the treatment of osteoarthritis, with the potential to slow cartilage degene - Doxycycline plus ivermectin versus ivermectin alone for treatment of patients with onchocerciasis
Cochrane Systematic Reviews, 15-Jan-2016
Onchocerciasis, also known as "river blindness," is a parasitic disease that is caused by infection from the filarial nematode (roundworm), Onchocerca volvulus. Nematodes are transmitted from person to person by blackflies of the Simulium genus, which usu - D‐Penicillamine for preventing retinopathy of prematurity in preterm infants
Cochrane Systematic Reviews, 3-Sep-2013
The rate of retinopathy of prematurity (ROP) in moderately premature infants has decreased dramatically with improved care in the neonatal intensive care unit. A low rate of this disorder was unexpectedly observed among infants treated with intravenous D- - D‐penicillamine for primary biliary cirrhosis
Cochrane Systematic Reviews, 18-Oct-2004
D-penicillamine is used for patients with primary biliary cirrhosis due to its hepatic copper decreasing and immunomodulatory potentials. The results from randomised clinical trials have been inconsistent. - D‐penicillamine for primary sclerosing cholangitis
Cochrane Systematic Reviews, 25-Jan-2006
Primary sclerosing cholangitis is a cholestatic disease. D-penicillamine is suggested as a treatment option due to its copper reducing and immunomodulatory potential. - Drama therapy for schizophrenia or schizophrenia-like illnesses
Cochrane Systematic Reviews, 23-Apr-2008
Medication is the mainstay of treatment for schizophrenia or schizophrenia-like illnesses, but many people continue to experience symptoms in spite of medication (Johnstone 1998). In addition to medication, creative therapies, such as drama therapy may pr - Dressings and securement devices for central venous catheters (CVC)
Cochrane Systematic Reviews, 11-Sep-2015
Central venous catheters (CVCs) play a vital role in the management of acute and chronic illness. Dressings and securement devices must ensure CVCs do not dislodge or fall out, provide a barrier protection from microbial colonisation and infection, and be - Dressings and topical agents for arterial leg ulcers
Cochrane Systematic Reviews, 20-Jan-2020
It is estimated that up to 1% of people in high-income countries suffer from a leg ulcer at some time in their life. The majority of leg ulcers are associated with circulation problems; poor blood return in the veins causes venous ulcers (around 70% of ul - Dressings and topical agents for preventing pressure ulcers
Cochrane Systematic Reviews, 6-Dec-2018
Pressure ulcers, localised injuries to the skin or underlying tissue, or both, occur when people cannot reposition themselves to relieve pressure on bony prominences. These wounds are difficult to heal, painful, expensive to manage and have a negative imp - Dressings and topical agents for surgical wounds healing by secondary intention
Cochrane Systematic Reviews, 26-Jan-2004
Many different wound dressings and topical applications are used to cover surgical wounds healing by secondary intention. It is not known whether these dressings heal wounds at different rates. - Dressings and topical agents for treating pressure ulcers
Cochrane Systematic Reviews, 22-Jun-2017
Pressure ulcers, also known as bedsores, decubitus ulcers and pressure injuries, are localised areas of injury to the skin or the underlying tissue, or both. Dressings are widely used to treat pressure ulcers and promote healing, and there are many option - Dressings and topical agents for treating venous leg ulcers
Cochrane Systematic Reviews, 15-Jun-2018
Venous leg ulcers are open skin wounds on the lower leg which can be slow to heal, and are both painful and costly. The point prevalence of open venous leg ulcers in the UK is about 3 cases per 10,000 people, and many people experience recurrent episodes - Dressings for healing venous leg ulcers
Cochrane Systematic Reviews, 6-May-2014
Venous leg ulcers, sometimes called varicose or stasis ulcers, are a consequence of damage to the valves in the veins of the legs, leading to raised venous pressure. Venous ulcers are characterised by a cyclical pattern of healing and recurrence. The main - Dressings for superficial and partial thickness burns
Cochrane Systematic Reviews, 28-Mar-2013
An acute burn wound is a complex and evolving injury. Extensive burns produce systemic consequences, in addition to local tissue damage. Treatment of partial thickness burn wounds is directed towards promoting healing and a wide variety of dressings are c
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