- D-cycloserine for Alzheimer's disease
Cochrane Systematic Reviews, 5-May-2008
Evidence supports a role for NMDA receptors in learning and memory. These can be modulated by the antibiotic D-cycloserine in such a way that the effect of the excitatory transmitter substance glutamate is enhanced. A study on healthy subjects pretreated - D‐dimer test for excluding the diagnosis of pulmonary embolism
Cochrane Systematic Reviews, 5-Aug-2016
Pulmonary embolism (PE) can occur when a thrombus (blood clot) travels through the veins and lodges in the arteries of the lungs, producing an obstruction. People who are thought to be at risk include those with cancer, people who have had a recent surgic - Death audits and reviews for reducing maternal, perinatal and child mortality
Cochrane Systematic Reviews, 25-Mar-2020
The United Nations' Sustainable Development Goals (SDGs) include reducing the global maternal mortality rate to less than 70 per 100,000 live births and ending preventable deaths of newborns and children under five years of age, in every country, by 2030. - Debridement for surgical wounds
Cochrane Systematic Reviews, 5-Sep-2013
Surgical wounds that become infected are often debrided because clinicians believe that removal of this necrotic or infected tissue will expedite wound healing. There are numerous methods available but no consensus on which one is most effective for surgi - Debridement for venous leg ulcers
Cochrane Systematic Reviews, 14-Sep-2015
Venous ulcers (also known as varicose or venous stasis ulcers) are a chronic, recurring and debilitating condition that affects up to 1% of the population. Best practice documents and expert opinion suggests that the removal of devitalised tissue from ven - Debridement of diabetic foot ulcers
Cochrane Systematic Reviews, 20-Jan-2010
Foot ulceration is thought to affect 15% of people with diabetes at some time in their lives. Debridement is widely regarded as an effective intervention to speed up ulcer healing. The most effective method is unclear. - Debriefing interventions for the prevention of psychological trauma in women following childbirth
Cochrane Systematic Reviews, 13-Apr-2015
Childbirth is a complex life event that can be associated with both positive and negative psychological responses. When giving birth is experienced as particularly traumatic this can have a negative impact on a woman’s postnatal emotional well-being. Ther - Debulking hysterectomy followed by chemoradiotherapy versus chemoradiotherapy for FIGO stage (2019) IB3/II cervical cancer
Cochrane Systematic Reviews, 16-Sep-2022
With an estimated 570,000 new cases reported globally in 2018, and increasing numbers of new cases in countries without established human papillomavirus (HPV) vaccination programmes, cervical cancer is the third most common cancer in women worldwide. The - Decentralising HIV treatment in lower‐ and middle‐income countries
Cochrane Systematic Reviews, 27-Jun-2013
Policy makers, health staff and communities recognise that health services in lower- and middle-income countries need to improve people's access to HIV treatment and retention to treatment programmes. One strategy is to move antiretroviral delivery from h - Decision aids for people considering taking part in clinical trials
Cochrane Systematic Reviews, 27-Nov-2015
Several interventions have been developed to promote informed consent for participants in clinical trials. However, many of these interventions focus on the content and structure of information (e.g. enhanced information or changes to the presentation for - Decision aids for people facing health treatment or screening decisions
Cochrane Systematic Reviews, 12-Apr-2017
Decision aids are interventions that support patients by making their decisions explicit, providing information about options and associated benefits/harms, and helping clarify congruence between decisions and personal values. - Decision coaching for people making healthcare decisions
Cochrane Systematic Reviews, 8-Nov-2021
Decision coaching is non-directive support delivered by a healthcare provider to help patients prepare to actively participate in making a health decision. ‘Healthcare providers’ are considered to be all people who are engaged in actions whose primary int - Decision‐support tools via mobile devices to improve quality of care in primary healthcare settings
Cochrane Systematic Reviews, 27-Jul-2021
The ubiquity of mobile devices has made it possible for clinical decision-support systems (CDSS) to become available to healthcare providers on handheld devices at the point-of-care, including in low- and middle-income countries. The use of CDSS by provid - Decompressive craniectomy for the treatment of high intracranial pressure in closed traumatic brain injury
Cochrane Systematic Reviews, 31-Dec-2019
High intracranial pressure (ICP) is the most frequent cause of death and disability after severe traumatic brain injury (TBI). It is usually treated with general maneuvers (normothermia, sedation, etc.) and a set of first-line therapeutic measures (modera - Decompressive surgery for treating nerve damage in leprosy
Cochrane Systematic Reviews, 12-Dec-2012
Leprosy causes nerve damage which may result in nerve function impairment and disability. Decompressive surgery is used for treating nerve damage, although the effect is uncertain. This is an update of a review first published in 2009 and previously updat - Decompressive surgery of lower limbs for symmetrical diabetic peripheral neuropathy
Cochrane Systematic Reviews, 28-Feb-2011
Symmetrical peripheral neuropathy is a common complication of diabetic neuropathy. No treatments are known to be effective for progressive pain and sensory loss associated with diabetic neuropathy. Alternative effective treatment strategies have been soug - Decongestants, antihistamines and nasal irrigation for acute sinusitis in children
Cochrane Systematic Reviews, 27-Oct-2014
The efficacy of decongestants, antihistamines and nasal irrigation in children with clinically diagnosed acute sinusitis has not been systematically evaluated. - Deep anterior lamellar keratoplasty versus penetrating keratoplasty for treating keratoconus
Cochrane Systematic Reviews, 10-Jul-2014
Keratoconus is an ectatic (weakening) disease of the cornea, which is the clear surface at the front of the eye. Approximately 10% to 15% of patients diagnosed with keratoconus require corneal transplantation. This may be full-thickness (penetrating) or p - Deep brain and cortical stimulation for epilepsy
Cochrane Systematic Reviews, 18-Jul-2017
Despite optimal medical treatment, including epilepsy surgery, many epilepsy patients have uncontrolled seizures. Since the 1970s interest has grown in invasive intracranial neurostimulation as a treatment for these patients. Intracranial stimulation incl - Deep brain stimulation for dystonia
Cochrane Systematic Reviews, 10-Jan-2019
Dystonia is a painful and disabling disorder, characterised by painful, involuntary posturing of the affected body region(s). Deep brain stimulation is an intervention typically reserved for severe and drug-refractory cases, although uncertainty exists re
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