- Dermoscopy, with and without visual inspection, for diagnosing melanoma in adults
Cochrane Systematic Reviews, 20-Dec-2018
Melanoma has one of the fastest rising incidence rates of any cancer. It accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. Although history-taking and visual inspection of a suspicious lesion b - Descemet's membrane endothelial keratoplasty (DMEK) versus Descemet's stripping automated endothelial keratoplasty (DSAEK) for corneal endothelial failure
Cochrane Systematic Reviews, 14-Jun-2018
Corneal endothelial transplantation has become the gold standard for the treatment of corneal endothelial dysfunctions, replacing full thickness transplantation, known as penetrating keratoplasty. Corneal endothelial transplantation has been described usi - Desferrioxamine mesylate for managing transfusional iron overload in people with transfusion‐dependent thalassaemia
Cochrane Systematic Reviews, 22-Aug-2013
Thalassaemia major is a genetic disease characterised by a reduced ability to produce haemoglobin. Management of the resulting anaemia is through red blood cell transfusions. - Desipramine for neuropathic pain in adults
Cochrane Systematic Reviews, 22-Oct-2019
Antidepressants are widely used to treat chronic neuropathic pain (pain due to nerve damage), usually in doses below those at which they exert antidepressant effects. An earlier review that included all antidepressants for neuropathic pain is being replac - Desmopressin acetate (DDAVP) for preventing and treating acute bleeds during pregnancy in women with congenital bleeding disorders
Cochrane Systematic Reviews, 13-Feb-2019
Congenital bleeding disorders can cause obstetric haemorrhage during pregnancy, labour and following delivery. Desmopressin acetate (DDAVP) is found to be an effective drug which can reduce the risk of haemorrhage and can also stop bleeding in certain con - Desmopressin for nocturnal enuresis in children
Cochrane Systematic Reviews, 5-Nov-2008
Enuresis (bed-wetting) is a socially disruptive and stressful condition which affects from 15% to 20% of five year olds, and up to 2% of young adults. - Desmopressin for treating nocturia in men
Cochrane Systematic Reviews, 16-Aug-2018
Nocturia is the bothersome symptom of awakening one or more times per night to void. Desmopressin is a commonly used medication for treating nocturia. - Desmopressin use for minimising perioperative blood transfusion
Cochrane Systematic Reviews, 4-Jul-2017
Blood transfusion is administered during many types of surgery, but its efficacy and safety are increasingly questioned. Evaluation of the efficacy of agents, such as desmopressin (DDAVP; 1-deamino-8-D-arginine-vasopressin), that may reduce perioperative - Detoxification treatments for opiate dependent adolescents
Cochrane Systematic Reviews, 28-Apr-2014
The scientific literature examining effective treatments for opioid dependent adults clearly indicates that pharmacotherapy is a necessary and acceptable component of effective treatments for opioid dependence. Nevertheless, no studies have been published - Development of type 2 diabetes mellitus in people with intermediate hyperglycaemia
Cochrane Systematic Reviews, 26-Nov-2018
Intermediate hyperglycaemia (IH) is characterised by one or more measurements of elevated blood glucose concentrations, such as impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and elevated glycosylated haemoglobin A1c (HbA1c). These level - Developmental care for promoting development and preventing morbidity in preterm infants
Cochrane Systematic Reviews, 10-Nov-2008
Preterm infants experience a range of morbidity related to the immaturity of their organ systems and to concurrent disease states. There is concern that an unfavourable environment in the neonatal intensive care unit (NICU) may compound this morbidity. Mo - Device-modified trabeculectomy for glaucoma
Cochrane Systematic Reviews, 30-Nov-2015
Glaucoma is an optic neuropathy that leads to vision loss and blindness. It is the second most common cause of irreversible blindness worldwide. The main treatment for glaucoma aims to reduce intraocular pressure (IOP) in order to slow or prevent further - Devices and dressings to secure peripheral venous catheters to prevent complications
Cochrane Systematic Reviews, 11-Jun-2015
A peripheral venous catheter (PVC) is typically used for short-term delivery of intravascular fluids and medications. It is an essential element of modern medicine and the most frequent invasive procedure performed in hospitals. However, PVCs often fail b - Devices and pressure sources for administration of nasal continuous positive airway pressure (NCPAP) in preterm neonates
Cochrane Systematic Reviews,
Nasal continuous positive airway pressure (NCPAP) is used to support preterm infants recently extubated, those experiencing significant apnoea of prematurity and those with respiratory distress soon after birth as an alternative to intubation and ventilat - Devices for preventing percutaneous exposure injuries caused by needles in healthcare personnel
Cochrane Systematic Reviews, 8-Nov-2017
Percutaneous exposure injuries from devices used for blood collection or for injections expose healthcare workers to the risk of blood borne infections such as hepatitis B and C, and human immunodeficiency virus (HIV). Safety features such as shields or r - Dexamethasone as an adjuvant to peripheral nerve block
Cochrane Systematic Reviews, 9-Nov-2017
Peripheral nerve block (infiltration of local anaesthetic around a nerve) is used for anaesthesia or analgesia. A limitation to its use for postoperative analgesia is that the analgesic effect lasts only a few hours, after which moderate to severe pain at - Dexmedetomidine for the management of awake fibreoptic intubation
Cochrane Systematic Reviews,
Awake fibreoptic intubation (AFOI) frequently requires sedation, anxiolysis and relief of discomfort without impairing ventilation and depressing cardiovascular function. The goal is to allow the patient to be responsive and co-operative. Medications such - Diacerein for osteoarthritis
Cochrane Systematic Reviews, 7-Feb-2014
Osteoarthritis (OA) is one of the most prevalent musculoskeletal diseases. There is currently no consensus on what is the best treatment to improve OA symptoms and slow disease progression. Diacerein is an anthraquinone synthesised in 1980 that interferes - Diagnostic accuracy of different imaging modalities following computed tomography (CT) scanning for assessing the resectability with curative intent in pancreatic and periampullary cancer
Cochrane Systematic Reviews, 13-Sep-2016
Periampullary cancer includes cancer of the head and neck of the pancreas, cancer of the distal end of the bile duct, cancer of the ampulla of Vater, and cancer of the second part of the duodenum. Surgical resection is the only established potentially cur - Diagnostic accuracy of endoscopic ultrasonography (EUS) for the preoperative locoregional staging of primary gastric cancer
Cochrane Systematic Reviews, 5-Feb-2015
Endoscopic ultrasound (EUS) is proposed as an accurate diagnostic device for the locoregional staging of gastric cancer, which is crucial to developing a correct therapeutic strategy and ultimately to providing patients with the best chance of cure. Howev
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