- De‐intensified adjuvant (chemo)radiotherapy versus standard adjuvant chemoradiotherapy post transoral minimally invasive surgery for resectable HPV‐positive oropharyngeal carcinoma
Cochrane Systematic Reviews, 14-Dec-2018
More than 400,000 cases of oropharyngeal squamous cell cancer (OPSCC) are diagnosed every year worldwide and this is rising. Much of the increase has been attributed to human papillomavirus (HPV). HPV-positive OPSCC patients are often younger and have sig - Delayed antibiotic prescriptions for respiratory infections
Cochrane Systematic Reviews, 7-Sep-2017
Concerns exist regarding antibiotic prescribing for respiratory tract infections (RTIs) owing to adverse reactions, cost, and antibacterial resistance. One proposed strategy to reduce antibiotic prescribing is to provide prescriptions, but to advise delay - Delayed introduction of progressive enteral feeds to prevent necrotising enterocolitis in very low birth weight infants
Cochrane Systematic Reviews, 20-Jan-2022
Enteral feeding for very preterm or very low birth weight (VLBW) infants is often delayed for several days after birth due to concern that early introduction of feeding may not be tolerated and may increase the risk of necrotising enterocolitis. Concerns - Deliberate hypotension with propofol under anaesthesia for functional endoscopic sinus surgery (FESS)
Cochrane Systematic Reviews, 12-Oct-2016
Functional endoscopic sinus surgery (FESS) is a minimally invasive technique that is used to treat chronic sinusitis. Small bleeding areas can reduce operative visibility and result in destruction of surrounding structures. Deliberate hypotension (lowerin - Delivery arrangements for health systems in low‐income countries: an overview of systematic reviews
Cochrane Systematic Reviews, 13-Sep-2017
Delivery arrangements include changes in who receives care and when, who provides care, the working conditions of those who provide care, coordination of care amongst different providers, where care is provided, the use of information and communication te - Dengzhanhua preparations for acute cerebral infarction
Cochrane Systematic Reviews, 29-May-2008
Dengzhanhua preparations are widely used in China. Many controlled trials have been undertaken to investigate the efficacy of dengzhanhua preparations in the treatment of acute cerebral infarction. - Dental auxiliaries for dental care traditionally provided by dentists
Cochrane Systematic Reviews, 19-Aug-2014
Poor or inequitable access to oral health care is commonly reported in high-, middle- and low-income countries. Although the severity of these problems varies, a lack of supply of dentists and their uneven distribution are important factors. Delegating ca - Dental cavity liners for Class I and Class II resin‐based composite restorations
Cochrane Systematic Reviews, 5-Mar-2019
Resin-based composite (RBC) is currently accepted as a viable material for the restoration of caries for posterior permanent teeth requiring surgical treatment. Despite the fact that the thermal conductivity of the RBC restorative material closely approxi - Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications
Cochrane Systematic Reviews, 28-Feb-2013
Radiotherapy as part of head and neck cancer treatment leaves patients requiring much dental rehabilitation in a compromised environment that is difficult for the patient and the dental team to manage. - Dental fillings for the treatment of caries in the primary dentition
Cochrane Systematic Reviews, 17-Oct-2016
Childhood caries (tooth decay) consists of a form of tooth decay that affects the milk teeth (also known as baby or primary teeth) of children. This may range from tooth decay in a single tooth to rampant caries affecting all the teeth in the mouth. Prima - Depot fluspirilene for schizophrenia
Cochrane Systematic Reviews, 24-Jan-2007
Antipsychotic drugs are the mainstay treatment for schizophrenia and similar psychotic disorders. Long-acting depot injections of drugs such as fluspirilene are extensively used as a means of long-term maintenance treatment. - Depot haloperidol decanoate for schizophrenia
Cochrane Systematic Reviews, 25-Jan-1999
The mainstay of treatment for schizophrenia is the antipsychotic group of drugs. These are usually given orally but compliance with medication given by this route may be difficult to quantify. Problems with treatment adherence are common. The development - Depot medroxyprogesterone versus Norethisterone oenanthate for long-acting progestogenic contraception.
Cochrane Systematic Reviews, 7-Mar-2012
There are two injectable progestogen-only contraceptives (IPCs) that have been available in many countries in the world since 1983. They are both still extensively used in many developing countries, forming a large proportion of the health system's expend - Depot perphenazine decanoate and enanthate for schizophrenia
Cochrane Systematic Reviews, 20-Jul-2005
Antipsychotic drugs are usually given orally but compliance with medication given by this route may be difficult to quantify. The development of depot injections in the 1960s gave rise to extensive use of depots as a means of long-term maintenance treatme - Depot pipotiazine palmitate and undecylenate for schizophrenia
Cochrane Systematic Reviews, 19-Jul-2004
Antipsychotic drugs are usually given orally but compliance may be problematic. The development of depot injections in the 1960s gave rise to their extensive use as a means of long-term maintenance treatment. Pipotiazine palmitate is a depot from the phen - Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down regulation in assisted reproduction cycles
Cochrane Systematic Reviews, 31-Jan-2013
Gonadotrophin-releasing hormone agonist (GnRHa) is commonly used to switch off (down regulate) the pituitary gland and thus suppress ovarian activity in women undergoing in vitro fertilisation (IVF). Other fertility drugs (gonadotrophins) are then used to - Deprescribing versus continuation of chronic proton pump inhibitor use in adults
Cochrane Systematic Reviews, 16-Mar-2017
Proton pump inhibitors (PPIs) are a class of medications that reduce acid secretion and are used for treating many conditions such as gastroesophageal reflux disease (GERD), dyspepsia, reflux esophagitis, peptic ulcer disease, and hypersecretory condition - Dermoscopy, with and without visual inspection, for diagnosing melanoma in adults
Cochrane Systematic Reviews, 4-Dec-2018
Melanoma has one of the fastest rising incidence rates of any cancer. It accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. Although history-taking and visual inspection of a suspicious lesion b - Descemet's membrane endothelial keratoplasty (DMEK) versus Descemet's stripping automated endothelial keratoplasty (DSAEK) for corneal endothelial failure
Cochrane Systematic Reviews, 25-Jun-2018
Corneal endothelial transplantation has become the gold standard for the treatment of corneal endothelial dysfunctions, replacing full thickness transplantation, known as penetrating keratoplasty. Corneal endothelial transplantation has been described usi - Desferrioxamine mesylate for managing transfusional iron overload in people with transfusion‐dependent thalassaemia
Cochrane Systematic Reviews, 21-Aug-2013
Thalassaemia major is a genetic disease characterised by a reduced ability to produce haemoglobin. Management of the resulting anaemia is through red blood cell transfusions.
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