- Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Epilepsy affects approximately 1% of the population, with up to 30% of patients continuing to have seizures, despite antiepileptic drug treatment. Clobazam is a 1,5-benzodiazepine and is commonly used as an add-on treatment for drug-resistant epilepsy. Th - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Spasticity commonly affects patients with motor neuron disease. It is likely to contribute to worsening muscle dysfunction, increased difficulty with activities of daily living and deteriorating quality of life. This is an update of a review first publish - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Various rehabilitation treatments may be offered following carpal tunnel syndrome (CTS) surgery. The effectiveness of these interventions remains unclear. This is the first update of a review first published in 2013. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Meralgia paraesthetica is a clinical syndrome for which a number of treatments are in common use, including conservative measures, injection of corticosteroid with local anaesthetic and surgery. We aimed to examine the evidence for the relative efficacy o - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Many people with schizophrenia continue to experience symptoms despite conventional treatments being used. Alternative therapies such as hypnosis, in conjunction with conventional treatments, may be helpful. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Risperidone is the first new generation antipsychotic drug made available in a long-acting injection formulation. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Schizophrenia is usually considered an illness of young adulthood. However, onset after the age of 40 years is reported in 23% of patients hospitalised with schizophrenia. At least 0.1% of the world's elderly population have a diagnosis of late-onset schi - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Fibrin sealants (also referred to as biological glue or fibrin tissue adhesives) have gained increasing popularity as interventions to improve peri-operative (intra- and post-operative) haemostasis and diminish the need for allogeneic red cell transfusion - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Concerns regarding the safety of transfused blood have generated considerable enthusiasm for the use of technologies intended to reduce the use of allogeneic blood (blood from an unrelated donor). Platelet-rich plasmapheresis (PRP) offers an alternative a - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Injury is responsible for an increasing global burden of death and disability. As a result, new models of trauma care have been developed. Many of these, though initially developed in high-income countries (HICs), are now being adopted in low and middle-i - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Post-thrombotic syndrome (PTS) is a long-term complication of deep vein thrombosis (DVT) that is characterised by chronic pain, swelling, and skin changes in the affected limb. One of every three people with DVT will develop post-thrombotic complications - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
An ignition interlock device is part of a multi-dimensional programme aimed at reducing recidivism in convicted drink drivers. To operate a vehicle equipped with an ignition interlock device, the driver must first provide a breath specimen. If the breath - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Hypotonic saline (such as 0.18-0.3% NaCl with dextrose) is commonly used as maintenance fluid in the management of acute infections. In recent years there have been numerous reports of hypotonic saline solutions being associated with adverse outcomes. To - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Post-thrombotic syndrome (PTS) is a long-term complication of deep vein thrombosis (DVT) characterised by chronic complaints such as oedema and skin changes including; venous ectasia, varicose veins, redness, eczema, hyperpigmentation, and in severe cases - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Hepatitis C is a major cause of liver-related morbidity and mortality. Standard therapy is ribavirin plus pegylated interferon to achieve undetectable level of virus in the blood, but the effect on clinical outcomes is controversial. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Falls in care facilities and hospitals are common events that cause considerable morbidity and mortality for older people. This is an update of a review first published in 2010 and updated in 2012. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Chemotherapeutic agents such as topotecan can be used as salvage treatment in epithelial ovarian carcinoma (EOC). The effects of using topotecan as a therapeutic agent have not been previously been systematically reviewed. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Pneumocystis pneumonia (PCP) is a disease affecting immunocompromised patients. PCP among these patients is associated with significant morbidity and mortality. - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Alzheimer's disease (AD) has become a major public health problem around the world due to its increasing prevalence, long duration, caregiver burden, and high financial cost of care. The degeneration of acetylcholine-containing neurons in the basal forebr - Cochrane Database of Systematic Reviews
Cochrane Systematic Reviews,
Previous research has shown that the prophylactic use of uterotonic agents in the third stage of labour reduces postpartum blood loss and moderate to severe postpartum haemorrhage (PPH). PPH is defined as a blood loss of 500 mL or more within 24 hours aft
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