Upcoming Topics

Essential Evidence Plus (EE+) was designed around a validated scheme for classifying the questions of physicians. The Editor in Chief, Dr Mark Ebell and colleagues originally identified 57 generic types of questions, such as "What is the best drug x for disease y?"1 Dr Ebell collapsed some of those categories into the current scheme for EE+, to assure that all of the key questions of a practicing physician are addressed by each EE+ topic.2 The original topic list of 800 topics was based on a review of the most common conditions seen by primary care doctors based on the US National Ambulatory Medical Care Survey, and a careful review of the tables of contents of standard medical references.

1. Ely JW, Osheroff JA, Ebell MH, Bergus GR, Levy BT, Chambliss ML, Evans ER. Analysis of questions asked by family doctors regarding patient care. BMJ. 1999 Aug 7;319(7206):358-61.
2. Ely JW, Osheroff JA, Gorman PN, Ebell MH, Chambliss ML, Pifer EA, Stavri PZ. A taxonomy of generic clinical questions: classification study. BMJ. 2000 Aug 12;321(7258):429-32.

The following topics represent those from the original 800 that we intend to develop in the future:

  • Barrett's esophagus
  • Parasomnias of REM
  • Anticoagulation management
  • Acid-base abnormalities
  • Chronic anxiety
  • Dehydration (child)
  • Eclampsia and pre-eclampsia
  • Grave's disease
  • Henoch-Schoenlein Purpura
  • Hepatomegaly
  • Hypertriglyceridemia and low HDL
  • Leukemia (chronic lymphocytic)
  • Metabolic syndrome
  • Pancreatitis (chronic)
  • Pregnancy induced hypertension
  • Apnea (neonatal)
  • Ataxia
  • Atrial and ventricular septal defects
  • Biliary atresia
  • Bronchiolitis obliterans
  • Bronchopulmonary dysplasia
  • Choledocholithiasis
  • Cocaine use
  • Congenital heart disease
  • Cutaneous T Cell Lymphoma
  • Cyclospora
  • Dacrocystitis
  • Dystonic reaction
  • Endophthalmitis
  • Fracture (hip and pelvis)
  • Gastric outlet obstruction
  • Hemolytic disease (newborn)
  • Hernia (umbilical)
  • Histiocytosis
  • Horner's syndrome
  • Hypertensive nephropathy
  • Hypoaldosteronism (Addison disease)
  • Immunodeficiency syndromes
  • Intussusception
  • Kuru, Kreutzfield-Jacob and prion diseases
  • Lacrimal duct obstruction
  • Leishmaniasis
  • Lightning injury
  • Lymphoma (Burkitt)
  • Lymphoma (hairy cell)
  • Lymphoma (MALT)
  • Methemoglobinemia
  • Necrotizing Entercolitis
  • Ocular chemical exposure and burns
  • Photosensitivity and photodermatitis
  • Post-partum (puerperal) infection
  • Rotavirus infection
  • Rubeola
  • Severe acute respiratory syndrome (SARS)
  • Sick sinus syndrome
  • Smallpox
  • Stomatitis
  • Stuttering and stammering
  • Thalassemia
  • Thrombophlebitis
  • Thyroiditis
  • Toxoplasmosis
  • Trichinosis
  • Uterine and rectal prolapse
  • Uveitis
  • Vulvar malignancy
  • Boutonneuse fever
  • African tick bite fever
  • Aneurysm (other)
  • Choking
  • Congenital megacolon
  • Corneal burns
  • Cyanide
  • Cysticercosis
  • Echinococcosis
  • Entamoeba histolytica
  • Erythroblastosis Fetalis
  • Flail chest
  • Floppy infant syndrome
  • Foreign body (nasal, ear)
  • Fracture (nasal/facial)
  • Fracture (wrist) in child
  • Gastroenteritis (viral)
  • Glossitis
  • Geographic tongue
  • Gunshot wound
  • Hernia (diaphragmatic)
  • Hernia (femoral)
  • Injection (deltoid bursa)
  • Irritant gas exposure
  • Learning disabilities
  • Legg-Calve-Perthes Disease
  • Nephrotic syndrome
  • Osteitis deformans
  • Paget's disease of breast
  • Pain management (acute)
  • Portal hypertension and esophageal varices
  • Refractive errors and correction
  • Rh isoimmunization
  • Rickettsial pox
  • Spinal tumors
  • Subphrenic abscess
  • Teratoma
  • Tracheitis
  • Wiskott Aldrich Syndrome